Hauser M A, Koob M D, Roth J A
Am J Vet Res. 1986 Jan;47(1):152-3.
Neutrophil function was evaluated on 2 occasions in 5 calves from each of the following age groups: 4 to 5 weeks, 9 to 11 weeks, 16 to 19 weeks, and 12 to 14 months. Of the neutrophil functions examined, the iodination reaction, which evaluates the activity of the myeloperoxidase-hydrogen peroxide-halide antibacterial system of the neutrophil, reflected the most marked differences among age groups. The iodination values for the 2 youngest age groups were approximately 52% of the value for the oldest cattle. This difference could not be attributed to the amount of myeloperoxidase in the neutrophil granules. Antibody-dependent cell-mediated cytotoxicity also tended to be lower in neutrophils from the 3 younger age groups. Nitroblue tetrazolium reduction, a measure of superoxide anion generation by neutrophils, was lower in the youngest age group only. The capability of neutrophils to ingest Staphylococcus aureus was higher in the 3 youngest groups of calves than in the oldest group. The observed differences in neutrophil function in young vs older calves may be partially responsible for the increased susceptibility of young calves to infectious disease.
对以下每个年龄组的5头犊牛分两次评估中性粒细胞功能：4至5周龄、9至11周龄、16至19周龄以及12至14月龄。在所检测的中性粒细胞功能中，评估中性粒细胞髓过氧化物酶-过氧化氢-卤化物抗菌系统活性的碘化反应在各年龄组间反映出最显著的差异。两个最年幼年龄组的碘化值约为最年长牛只碘化值的52%。这种差异不能归因于中性粒细胞颗粒中髓过氧化物酶的含量。抗体依赖性细胞介导的细胞毒性在3个较年幼年龄组的中性粒细胞中也往往较低。硝基蓝四氮唑还原试验（一种衡量中性粒细胞产生超氧阴离子的指标）仅在最年幼年龄组中较低。3个最年幼组犊牛的中性粒细胞摄取金黄色葡萄球菌的能力高于最年长组。在年幼犊牛与年长犊牛中观察到的中性粒细胞功能差异可能部分导致年幼犊牛对传染病易感性增加。
