Jenkins E M, Hurdle C
Br Vet J. 1989 Nov-Dec;145(6):565-72. doi: 10.1016/0007-1935(89)90119-X.
Leucocyte migration-inhibition and humoral antibody responses (HAR) were demonstrated in swine immunized with particulate or soluble antigen of Treponema hyodysenteriae. Levamisole (at the recommended deworming level), given simultaneously with particulate vaccine did not significantly (P greater than 0.05) enhance nor suppress the leucocyte migration-inhibition response. However, an enhancing leucocyte migration-inhibition of the drug was seen in pigs given soluble vaccine in combination with levamisole compared with those receiving soluble antigen alone. Levamisole generally suppressed the HAR throughout the immunization schedule of pigs given soluble or particulate vaccine. There was no significant suppression (P greater than 0.05) of clinical signs of swine dysentery (SD) in animals given particulate vaccine nor in those receiving this vaccine plus levamisole. However, pigs receiving soluble vaccine plus levamisole had fewer clinical signs of SD as well as significantly (P less than 0.05) fewer shedding episodes of T. hyodysenteriae than those given soluble antigen alone. When compared with the control pigs, swine vaccinated with soluble antigen had fewer days of total diarrhoea and shedding episodes of T. hyodysenteriae. However, the diarrhoea of vaccinated pigs was not significantly (P greater than 0.05) delayed when compared to the unvaccinated swine.
用猪痢疾密螺旋体的颗粒性或可溶性抗原免疫猪后，可观察到白细胞游走抑制和体液抗体反应（HAR）。与颗粒性疫苗同时给予左旋咪唑（按推荐的驱虫剂量），对白细胞游走抑制反应无显著增强或抑制作用（P>0.05）。然而，与仅接受可溶性抗原的猪相比，接受可溶性疫苗与左旋咪唑联合使用的猪出现了药物增强的白细胞游走抑制现象。在给予可溶性或颗粒性疫苗的猪的整个免疫过程中，左旋咪唑通常会抑制HAR。给予颗粒性疫苗的动物或接受该疫苗加左旋咪唑的动物，猪痢疾（SD）的临床症状均未受到显著抑制（P>0.05）。然而，与仅接受可溶性抗原的猪相比，接受可溶性疫苗加左旋咪唑的猪的SD临床症状较少，猪痢疾密螺旋体的排菌次数也显著减少（P<0.05）。与对照猪相比，用可溶性抗原接种疫苗的猪的总腹泻天数和猪痢疾密螺旋体的排菌次数较少。然而，与未接种疫苗的猪相比，接种疫苗的猪的腹泻并未显著延迟（P>0.05）。
