Glock R D, Schwartz K J, Harris D L
Am J Vet Res. 1978 Apr;39(4):639-42.
Six intravenous injections of formalin-inactivated Treponema hyodysenteriae were given to 8 specific-pathogen-free pigs at 6-day intervals. The 8 vaccinated and 8 control pigs were challenged intragastrically with pure cultures of T hyodysenteriae 7 and 8 days after the last intravenous injection. Clinical signs of swine dysentery were observed in all 8 control pigs, but was observed in only 1 of the immunized pigs. Three control pigs died. These findings suggest that parenteral immunization with T hyodysenteriae provided a marked degree of protection against subsequent intragastric challenge exposure with the homologous isolate of T hyodysenteriae.
给8头无特定病原体猪每隔6天进行6次静脉注射福尔马林灭活的猪痢疾密螺旋体。在最后一次静脉注射后7天和8天，对8头接种疫苗的猪和8头对照猪进行猪痢疾密螺旋体纯培养物灌胃攻毒。所有8头对照猪均出现猪痢疾的临床症状，但仅1头免疫猪出现该症状。3头对照猪死亡。这些结果表明，用猪痢疾密螺旋体进行非肠道免疫可提供显著程度的保护，防止随后用同源猪痢疾密螺旋体分离株进行灌胃攻毒。
