Dong Xiao-Hui, Sun Xin, Jiang Guo-Jun, Chen Alex F, Xie He-Hui
From the Department of Science for Identifying Chinese Materia Medica, The Second Military Medical University, Shanghai, China (X.-H.D., X.S., A.F.C., H.-H.X.); Department of Cardiology and Center of Clinical Pharmacology, Third Xiangya Hospital and the Institute of Vascular Disease and Translational Medicine, Central South University, Changsha, Hunan, China (A.F.C., H.-H.X.); and Department of Pharmacy, Xiaoshan Hospital, Hangzhou, China (G.-J.J.).
Stroke. 2015 Jun;46(6):1714-8. doi: 10.1161/STROKEAHA.114.007308. Epub 2015 Apr 23.
In our current food supply, sugar substitutes are widely used in beverages and other food products. However, there is limited information about the link between dietary consumption of sugar substitutes and stroke to date. This study sought to determine the effect of various sugar substitutes on the cerebral ischemic injury and endothelial progenitor cells, which have been implicated to play an important role in vascular repair and revascularization in ischemic brain tissues, in mice.
After treatment with sucrose and various sugar substitutes (the doses are in the range of corresponding acceptable daily intake levels) and vehicle for 6 weeks, mice were subjected to permanent left middle cerebral artery occlusion, and the infarct volumes, angiogenesis, and neurobehavioral outcomes were determined. In addition, the number and function of endothelial progenitor cells were also examined.
After long-term treatment with fructose, erythritol (sugar alcohols), acesulfame K (artificial sweeteners), or rebaudioside A (rare sugars), the cerebral ischemic injury (both infarct volumes and neurobehavioral outcomes) was significantly aggravated, angiogenesis in ischemic brain was reduced, and endothelial progenitor cell function was impaired in mice compared with control. However, the similar impairments were not found in sucrose (with the same dose as fructose's)-treated mice.
Long-term consumption of sugar substitutes aggravated cerebral ischemic injury in mice, which might be partly attributed to the impairment of endothelial progenitor cells and the reduction of angiogenesis in ischemic brain. This result implies that dietary intake of sugar substitutes warrants further attention in daily life.
在我们当前的食物供应中，糖替代品广泛应用于饮料及其他食品中。然而，迄今为止，关于糖替代品的饮食摄入与中风之间的联系的信息有限。本研究旨在确定各种糖替代品对小鼠脑缺血损伤和内皮祖细胞的影响，内皮祖细胞在缺血脑组织的血管修复和血管再生中被认为起着重要作用。
用蔗糖、各种糖替代品（剂量在相应的每日可接受摄入量范围内）和赋形剂处理小鼠6周后，对小鼠进行永久性左侧大脑中动脉闭塞，并测定梗死体积、血管生成和神经行为结果。此外，还检测了内皮祖细胞的数量和功能。
与对照组相比，用果糖、赤藓糖醇（糖醇类）、安赛蜜（人工甜味剂）或甜菊糖苷A（稀有糖）长期处理后，小鼠的脑缺血损伤（梗死体积和神经行为结果）明显加重，缺血脑组织中的血管生成减少，内皮祖细胞功能受损。然而，在蔗糖（与果糖剂量相同）处理的小鼠中未发现类似的损伤。
长期食用糖替代品会加重小鼠的脑缺血损伤，这可能部分归因于内皮祖细胞的损伤和缺血脑组织中血管生成的减少。这一结果表明，糖替代品的饮食摄入在日常生活中值得进一步关注。
