Lee Y H, Bae S-C, Choi S J, Ji J D, Song G G
Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea
The Hospital for Rheumatic Diseases, Hanyang University Medical Center, Seoul, Korea.
Lupus. 2015 Oct;24(11):1177-83. doi: 10.1177/0961203315583543. Epub 2015 Apr 23.
The aim of this study was to determine whether the functional CD40 rs4810485 G/T polymorphism is associated with susceptibility to rheumatoid arthritis (RA) or with susceptibility to systemic lupus erythematosus (SLE).
A series of meta-analyses were conducted to test for association between the CD40 rs4810485 G/T polymorphism and RA or SLE.
A total of 21 comparisons involving 15,095 patients and 27,050 controls for RA, and 1353 patients and 2342 controls for SLE were considered. Meta-analysis showed a significant association between the CD40 rs4810485 T allele and RA in all subjects (odds ratio (OR) 0.890, 95% confidence interval (CI) 0.846-0.936, p = 5.5 × 10(-7)). After stratification by ethnicity, the CD40 T allele was found to be significantly associated with RA in Europeans (OR 0.879, 95% CI 0.848-0.901, p = 3.0 × 10(-9)). A similar pattern of association was observed between the CD40 T allele and RA when the analysis was performed using the recessive, dominant, and additive models. Meta-analysis also showed a significant association between the CD40 polymorphism and SLE in Europeans (OR for the T allele 0.715, 95% CI 0.641-0.832, p = 1.4 × 10(-6)).
Our meta-analyses confirm that the CD40 rs4810485 G/T polymorphism is associated with susceptibility to RA and SLE in Europeans.
本研究旨在确定功能性CD40 rs4810485 G/T多态性是否与类风湿关节炎（RA）易感性或系统性红斑狼疮（SLE）易感性相关。
进行了一系列荟萃分析，以检测CD40 rs4810485 G/T多态性与RA或SLE之间的关联。
共纳入21项比较，涉及15095例RA患者和27050例对照，以及1353例SLE患者和2342例对照。荟萃分析显示，在所有受试者中，CD40 rs4810485 T等位基因与RA显著相关（优势比（OR）0.890，95%置信区间（CI）0.846 - 0.936，p = 5.5×10⁻⁷）。按种族分层后，发现CD40 T等位基因在欧洲人中与RA显著相关（OR 0.879，95%CI 0.848 - 0.901，p = 3.0×10⁻⁹）。当使用隐性、显性和加性模型进行分析时，在CD40 T等位基因与RA之间观察到类似的关联模式。荟萃分析还显示，在欧洲人中，CD40多态性与SLE显著相关（T等位基因的OR为0.715，95%CI 0.641 - 0.832，p = 1.4×10⁻⁶）。
我们的荟萃分析证实，CD40 rs4810485 G/T多态性与欧洲人患RA和SLE的易感性相关。
