Lee Y H, Bae S-C
Rheumatology, Korea University Medical Center.
Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea.
Cell Mol Biol (Noisy-le-grand). 2017 Feb 22;63(1):53-59. doi: 10.14715/cmb/2017.63.1.11.
This study systemically reviewed evidence regarding the relationship between circulating blood transforming growth factor-β1 (TGF-β1) levels and systemic lupus erythematous (SLE) and rheumatoid arthritis (RA), and associations between TGF-β1 polymorphisms and susceptibility to SLE and RA. We conducted a meta-analysis on the serum/plasma TGF-β1 levels in SLE and RA patients and healthy controls, and the associations between TGF-β1 +869 T/C, +915 C/G, and -509 T/C polymorphisms and SLE or RA risk. Twenty-eight studies were considered in this meta-analysis. Circulating TGF-β1 levels were significantly lower in the SLE group than in controls (SMD = -1.164, 95% CI = -2.257 - -0.070, P = 0.037). Serum/plasma TGF-β1 levels were not significantly different between RA and control groups (SMD = 0.699, 95% CI = -0.379 - 1.717, p = 0.211). No association between TGF-β1 +869 T/C polymorphism and SLE was found. However, meta-analysis showed an association between the TGF-β1 +869 T allele and RA in all subjects (OR = 1.282, 95% CI = 1.118-1.470, P = 3.8 x 10-4). Analysis after stratification by ethnicity indicated that the T allele was significantly associated with RA in Asians and Arabs (OR = 1.429, 95% CI = 1.179-1.733, P = 2.9 x 10-4; OR = 1.352, 95% CI = 1.097-1.668, P = 0.005), but not Europeans. However, no association was found between TGF-β1 +915 G/C or -509 C/T polymorphisms and RA or SLE. Meta-analysis revealed a significantly lower circulating TGF-β1 level in SLE patients, and a significant association between TGF-β1 +869 T/C polymorphism and RA development.
本研究系统评价了循环血中转化生长因子-β1（TGF-β1）水平与系统性红斑狼疮（SLE）和类风湿关节炎（RA）之间关系的证据，以及TGF-β1基因多态性与SLE和RA易感性之间的关联。我们对SLE和RA患者及健康对照者血清/血浆中TGF-β1水平，以及TGF-β1 +869 T/C、+915 C/G和 -509 T/C基因多态性与SLE或RA风险之间的关联进行了荟萃分析。本荟萃分析纳入了28项研究。SLE组循环TGF-β1水平显著低于对照组（标准化均数差[SMD]= -1.164，95%可信区间[CI]= -2.257至 -0.070，P = 0.037）。RA组与对照组血清/血浆TGF-β1水平无显著差异（SMD = 0.699，95% CI = -0.379至1.717，P = 0.211）。未发现TGF-β1 +869 T/C基因多态性与SLE之间存在关联。然而，荟萃分析显示在所有受试者中TGF-β1 +869 T等位基因与RA存在关联（比值比[OR]= 1.282，95% CI = 1.118至1.470，P = 3.8×10⁻⁴）。按种族分层后的分析表明，T等位基因在亚洲人和阿拉伯人中与RA显著相关（OR = 1.429，95% CI = 1.179至1.733，P = 2.9×10⁻⁴；OR = 1.352，95% CI = 1.097至1.668，P = 0.005），但在欧洲人中并非如此。然而，未发现TGF-β1 +915 G/C或 -509 C/T基因多态性与RA或SLE存在关联。荟萃分析显示SLE患者循环TGF-β1水平显著降低，且TGF-β1 +869 T/C基因多态性与RA发生之间存在显著关联。
