Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Shenzhen Graduate School of Peking University, Shenzhen 518055, China.
Org Lett. 2015 May 15;17(10):2522-5. doi: 10.1021/acs.orglett.5b01053. Epub 2015 Apr 24.
Mild and direct C-H bond functionalizations and vinylations of tetrahydrofuran with alkynes have been accomplished through visible light photocatalysis, yielding a range of vinyl tetrahydrofurans under the synergistic actions of organic dye-type photocatalyst eosin Y, tert-butyl hydroperoxide (t-BuOOH), and a 45 W household lightbulb. A significant kinetic isotope effect (KIE) was recorded, which helps shed light on the mechanistic course.
通过可见光光催化，实现了温和且直接的四氢呋喃与炔烃的 C-H 键官能化和乙烯基化反应，在有机染料型光催化剂曙红 Y、叔丁基过氧化氢（t-BuOOH）和 45 W 家用灯泡的协同作用下，得到了一系列的乙烯基四氢呋喃。实验记录了显著的动力学同位素效应（KIE），这有助于阐明反应的机理过程。
