van der Gaag I, Happé R P
Institute of Veterinary Pathology, State University Utrecht, The Netherlands.
Can J Vet Res. 1989 Oct;53(4):473-6.
The results of follow-up studies in 77 dogs with clinical signs of large bowel disease are presented. In 32 dogs colonic and/or rectal biopsy follow-up studies were done, combined with necropsy in seven dogs. In 45 dogs a follow-up necropsy only was done. The time between the first and the last series of biopsies varied from three to 729 days and between the first series of biopsies and necropsy from one to 980 days. Colitis found in 45 dogs in the initial biopsies was still present in 29 cases in the follow-up biopsy studies and/or at necropsy. Eleven cases showed hystiocytic ulcerative colitis. In general, adenoma, carcinoma and lymphosarcoma were confirmed in the follow-up examination, except for one adenoma, which appeared to be a carcinoma at necropsy. In cases in which the differential diagnosis was adenoma or carcinoma, the necropsy diagnosis was always carcinoma and in cases of a differential diagnosis of lymphosarcoma and/or colitis, lymphosarcoma was always diagnosed at necropsy. Several dogs without colonic changes in the initial biopsies had other gastric or small intestinal lesions at necropsy such as gastritis and enteritis of the small intestine, or tumors, in these areas.
本文呈现了对77只出现大肠疾病临床症状的犬类进行随访研究的结果。对32只犬进行了结肠和/或直肠活检随访研究，其中7只犬还进行了尸检。对45只犬仅进行了随访尸检。首次活检与最后一次活检之间的时间间隔为3至729天，首次活检与尸检之间的时间间隔为1至980天。在初始活检中发现45只犬患有结肠炎，在随访活检研究和/或尸检中，仍有29例存在结肠炎。11例显示为组织细胞性溃疡性结肠炎。总体而言，在随访检查中确诊了腺瘤、癌和淋巴肉瘤，但有一例腺瘤在尸检时被发现为癌。在鉴别诊断为腺瘤或癌的病例中，尸检诊断总是癌；在鉴别诊断为淋巴肉瘤和/或结肠炎的病例中，尸检总是诊断为淋巴肉瘤。几只在初始活检中无结肠病变的犬在尸检时出现了其他胃部或小肠病变，如胃炎、小肠肠炎或这些部位的肿瘤。
