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全基因组拷贝数变异图谱揭示了基因组组织可塑性并提出了新的迁移路线。

Global spectrum of copy number variations reveals genome organizational plasticity and proposes new migration routes.

作者信息

Veerappa Avinash M, Vishweswaraiah Sangeetha, Lingaiah Kusuma, Murthy Megha, Suresh Raviraj V, Manjegowda Dinesh S, Ramachandra Nallur B

机构信息

Genetics and Genomics Lab, Department of Studies in Zoology, University of Mysore, Manasagangotri, Mysore-06, Karnataka, India.

NUCSER, KS Hegde Medical Academy, Nitte University, Mangalore-18, Karnataka, India.

出版信息

PLoS One. 2015 Apr 24;10(4):e0121846. doi: 10.1371/journal.pone.0121846. eCollection 2015.

DOI:10.1371/journal.pone.0121846
PMID:25909454
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4409114/
Abstract

Global spectrum of CNVs is required to catalog variations to provide a high-resolution on the dynamics of genome-organization and human migration. In this study, we performed genome-wide genotyping using high-resolution arrays and identified 44,109 CNVs from 1,715 genomes across 12 populations. The study unraveled the force of independent evolutionary dynamics on genome-organizational plasticity across populations. We demonstrated the use of CNV tool to study human migration and identified a second major settlement establishing new migration routes in addition to existing ones.

摘要

需要全球范围内的拷贝数变异（CNV）图谱来对变异进行编目，以便在基因组组织和人类迁移动态方面提供高分辨率信息。在本研究中，我们使用高分辨率阵列进行全基因组基因分型，并在12个群体的1715个基因组中鉴定出44109个CNV。该研究揭示了不同群体中独立进化动力学对基因组组织可塑性的影响。我们展示了使用CNV工具来研究人类迁移，并确定了除现有迁移路线之外的第二条主要定居点，从而建立了新的迁移路线。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caa5/4409114/19f6f543aa51/pone.0121846.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caa5/4409114/9dbae74c1db9/pone.0121846.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caa5/4409114/39fd9a542d41/pone.0121846.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caa5/4409114/ebdc01c13164/pone.0121846.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caa5/4409114/19f6f543aa51/pone.0121846.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caa5/4409114/9dbae74c1db9/pone.0121846.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caa5/4409114/39fd9a542d41/pone.0121846.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caa5/4409114/ebdc01c13164/pone.0121846.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caa5/4409114/19f6f543aa51/pone.0121846.g004.jpg

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