Rešić Karara Jasminka, Zekić Tomas Sandra, Marušić Jelena, Roje Damir, Kuzmić Prusac Ivana
a Clinical Department of Gynecology and Obstetrics and.
b Clinical Department of Pathology , Split University Hospital Center , Split , Croatia.
J Matern Fetal Neonatal Med. 2016;29(7):1154-9. doi: 10.3109/14767058.2015.1038702. Epub 2015 Apr 24.
To compare the level of Fas and FasL immunohistochemical expression in villous trophoblast (VT), extravillous trophoblast (EVT) cells, decidual cells (DC), endothelial cells (EC) of villous blood vessels and spiral arteries between the study groups of intrauterine growth retardation (IUGR) placentas with and without preeclampsia (PE).
The study included 17 placentas from pregnancies complicated by IUGR + PE and 17 placentas from pregnancies complicated by idiopathic IUGR (I-IUGR). Seventeen placentas from normal pregnancies served as a control group. CD31 was used to detect endothelial cells (EC). Immunohistochemical expression of Fas and FasL was assessed in all examined parts of placenta using the semi-quantitative HSCORE method.
FasL expression was significantly higher in all examined parts of placenta in I-IUGR as compared to IUGR + PE and control group. Placentas with IUGR + PE had the significantly lowest expression of FasL in VT and EC of villi vessels. Expression of Fas did not differ significantly between the study groups.
Different expression of FasL in placentas from I-IUGR and IUGR + PE suggests that FasL probably has a different role in the etiology of these two syndromes.
比较伴有和不伴有子痫前期（PE）的宫内生长受限（IUGR）胎盘研究组中绒毛滋养层细胞（VT）、绒毛外滋养层细胞（EVT）、蜕膜细胞（DC）、绒毛血管和螺旋动脉内皮细胞（EC）中Fas和FasL免疫组化表达水平。
该研究包括17例合并IUGR + PE妊娠的胎盘和17例合并特发性IUGR（I-IUGR）妊娠的胎盘。17例正常妊娠的胎盘作为对照组。用CD31检测内皮细胞（EC）。采用半定量HSCORE法评估胎盘所有检查部位Fas和FasL的免疫组化表达。
与IUGR + PE组和对照组相比，I-IUGR组胎盘所有检查部位的FasL表达均显著更高。IUGR + PE胎盘在绒毛滋养层细胞和绒毛血管内皮细胞中的FasL表达显著最低。研究组之间Fas表达无显著差异。
I-IUGR和IUGR + PE胎盘FasL表达不同，提示FasL可能在这两种综合征的病因学中发挥不同作用。
