Fernandes Ricardo, Beserra Bruna T S, Mocellin Michel C, Kuntz Marilyn G F, da Rosa Julia S, de Miranda Rafaella C D, Schreiber Cristina S O, Fröde Tânia S, Nunes Everson A, Trindade Erasmo B S M
*Post-Graduate Program in Nutrition †Post-Graduate Program in Pharmacy ‡Polydoro Ernani de São Thiago University Hospital Departments of §Clinical Analysis and Post-Graduate Program in Pharmacy and in Medical Sciences ∥Physiology and Post-Graduate Program in Nutrition and in Physiological Sciences ¶Nutrition and Post-Graduate Program in Nutrition, Federal University of Santa Catarina, Florianópolis, Brazil.
J Clin Gastroenterol. 2016 Mar;50(3):208-17. doi: 10.1097/MCG.0000000000000328.
Studies have shown that prebiotics and synbiotics modulate the intestinal microbiota and may have beneficial effects on the immune response and anthropometric indices; however, the impact of the use of these supplements after bariatric surgery is not yet known.
This study investigated the effects of prebiotic and synbiotic supplementation on inflammatory markers and anthropometric indices in individuals undergoing open Roux-en-Y gastric bypass (RYGB).
In this randomized, controlled, and triple-blind trial conducted as a pilot study, individuals undergoing RYGB (n=9) and healthy individuals (n=9) were supplemented with 6 g/d of placebo (maltodextrin), prebiotic (fructo-oligosaccharide, FOS), or synbiotic (FOS+Lactobacillus and Bifidobacteria strains) for 15 days.
Interleukin-1β, interleukin-6, tumor necrosis factor-α, C-reactive protein, albumin, and the C-reactive protein/albumin ratio showed no significant changes on comparison between groups after supplementation. The reduction in the body weight of patients undergoing RYGB was 53.8% higher in the prebiotic group compared with the placebo group (-0.7 kg, P=0.001), whereas the reduction in the BMI and the increase in the percentage of excess weight loss were higher in the placebo and the prebiotic groups compared with the synbiotic group (P<0.05).
Supplementation of FOS increased weight loss, whereas both prebiotics and synbiotics were not able to promote significant changes in inflammatory markers, although in most analyses, there was a reduction in their absolute values. The use of FOS may represent a potential adjunct in the treatment of obesity.
研究表明，益生元和合生元可调节肠道微生物群，可能对免疫反应和人体测量指标产生有益影响；然而，减肥手术后使用这些补充剂的影响尚不清楚。
本研究调查了益生元和合生元补充剂对接受开放式Roux-en-Y胃旁路术（RYGB）的个体炎症标志物和人体测量指标的影响。
在这项作为试点研究进行的随机、对照、三盲试验中，接受RYGB的个体（n=9）和健康个体（n=9）被补充6克/天的安慰剂（麦芽糊精）、益生元（低聚果糖，FOS）或合生元（FOS+乳酸杆菌和双歧杆菌菌株），持续15天。
补充后，两组间白细胞介素-1β、白细胞介素-6、肿瘤坏死因子-α、C反应蛋白、白蛋白以及C反应蛋白/白蛋白比值均无显著变化。与安慰剂组相比，益生元组接受RYGB的患者体重减轻高出53.8%（-0.7千克，P=0.001），而与合生元组相比，安慰剂组和益生元组的BMI降低以及超重减轻百分比增加更高（P<0.05）。
补充FOS可增加体重减轻，而益生元和合生元均无法促进炎症标志物的显著变化，尽管在大多数分析中，其绝对值有所降低。使用FOS可能是治疗肥胖症的一种潜在辅助手段。
