Zhang Yu, Yan Tong, Xu Chenxin, Yang Huawu, Zhang Tongtong, Liu Yanjun
The Affiliated Hospital of Southwest Jiaotong University, Chengdu, China.
Department of Endocrinology and Metabolism, Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu, Chengdu, China.
Evid Based Complement Alternat Med. 2021 Apr 1;2021:5542626. doi: 10.1155/2021/5542626. eCollection 2021.
Whether probiotics could be used as an adjunct to bariatric surgery is controversial. This meta-analysis aimed to evaluate the effects of probiotics on body weight, body mass index (BMI), percentage of the excess weight loss (%EWL), waist circumference (WC), and C-reactive protein (CRP) in adults with obesity after bariatric surgery (BS). PUBMED, EMBASE, and the Cochrane Central Registry of Controlled Trials were searched from the earliest record to March 2020. All randomized controlled trials (RCTs) on the effects of probiotics in adults with obesity after bariatric surgery were analyzed according to the eligibility criteria. Four RCTs, including 172 participants, were analyzed. There was a statistically significant difference in probiotics in the reduction of waist circumference at 12 months after bariatric surgery. However, probiotics were not effective in weight, BMI, %EWL, WC, and CRP both within 3 months and at 12 months postoperation. Probiotics aid adults with morbid obesity in achieving further waist circumference improvement after BS, with no significant effect on weight, BMI, %EWL, and CRP. More quality clinical studies are needed to confirm the efficacy and safety of probiotics, and address a number of practical issues before the routine clinical use of probiotics in adults with obesity undergoing BS.
益生菌是否可作为减肥手术的辅助手段存在争议。这项荟萃分析旨在评估益生菌对减肥手术后肥胖成年人的体重、体重指数（BMI）、超重减轻百分比（%EWL）、腰围（WC）和C反应蛋白（CRP）的影响。检索了PUBMED、EMBASE和Cochrane对照试验中央注册库，检索时间从最早记录至2020年3月。根据纳入标准分析了所有关于益生菌对减肥手术后肥胖成年人影响的随机对照试验（RCT）。分析了4项RCT，包括172名参与者。减肥手术后12个月，益生菌在减小腰围方面存在统计学显著差异。然而，益生菌在术后3个月内和12个月时对体重、BMI、%EWL、WC和CRP均无效果。益生菌有助于病态肥胖成年人在减肥手术后进一步减小腰围，但对体重、BMI、%EWL和CRP无显著影响。需要更多高质量的临床研究来证实益生菌的疗效和安全性，并在肥胖成年人接受减肥手术时常规临床使用益生菌之前解决一些实际问题。
