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本文引用的文献

1
The primary cilium as sensor of fluid flow: new building blocks to the model. A review in the theme: cell signaling: proteins, pathways and mechanisms.作为流体感受器的初级纤毛:模型的新构建块。本期主题综述:细胞信号转导:蛋白质、途径和机制。
Am J Physiol Cell Physiol. 2015 Feb 1;308(3):C198-208. doi: 10.1152/ajpcell.00336.2014. Epub 2014 Nov 26.
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Regulation of STATs by polycystin-1 and their role in polycystic kidney disease.多囊蛋白-1对信号转导和转录激活因子(STATs)的调控及其在多囊肾病中的作用。
JAKSTAT. 2013 Apr 1;2(2):e23650. doi: 10.4161/jkst.23650.
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Asymmetric distribution of dynamic calcium signals in the node of mouse embryo during left-right axis formation.在左右轴形成过程中,小鼠胚胎节点内的动态钙信号呈不对称分布。
Dev Biol. 2013 Apr 1;376(1):23-30. doi: 10.1016/j.ydbio.2013.01.018. Epub 2013 Jan 25.
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Ciliary signaling cascades in photoreceptors.光感受器中的纤毛信号级联反应。
Vision Res. 2012 Dec 15;75:112-6. doi: 10.1016/j.visres.2012.08.007. Epub 2012 Aug 17.
5
mTOR signaling in polycystic kidney disease.mTOR 信号通路在多囊肾病中的作用。
Trends Mol Med. 2011 Nov;17(11):625-33. doi: 10.1016/j.molmed.2011.06.003. Epub 2011 Jul 19.
6
A role for the primary cilium in Notch signaling and epidermal differentiation during skin development.初级纤毛在 Notch 信号传导和皮肤发育过程中的表皮分化中的作用。
Cell. 2011 Jun 24;145(7):1129-41. doi: 10.1016/j.cell.2011.05.030.
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The primary cilium: a signalling centre during vertebrate development.初级纤毛:脊椎动物发育过程中的信号中心。
Nat Rev Genet. 2010 May;11(5):331-44. doi: 10.1038/nrg2774.
8
Growth arrest induces primary-cilium formation and sensitizes IGF-1-receptor signaling during differentiation induction of 3T3-L1 preadipocytes.生长停滞在3T3-L1前脂肪细胞分化诱导过程中诱导初级纤毛形成并使IGF-1受体信号敏感化。
J Cell Sci. 2009 Aug 1;122(Pt 15):2760-8. doi: 10.1242/jcs.046276. Epub 2009 Jul 13.
9
The electrochemical basis of odor transduction in vertebrate olfactory cilia.脊椎动物嗅觉纤毛中气味转导的电化学基础。
Chem Senses. 2008 Nov;33(9):839-59. doi: 10.1093/chemse/bjn048. Epub 2008 Aug 14.

简讯:纤毛的感知与信号传导

SnapShot: Sensing and Signaling by Cilia.

作者信息

Zimmerman Kurt, Yoder Bradley K

机构信息

Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

出版信息

Cell. 2015 Apr 23;161(3):692-692.e1. doi: 10.1016/j.cell.2015.04.015.

DOI:10.1016/j.cell.2015.04.015
PMID:25910215
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4757474/
Abstract

Primary cilia are cellular appendages that coordinate diverse sensory and signaling activities. They are important for proper mammalian development, adult tissue homeostasis, and vision and odorant detection, and their dysfunction contributes to disease pathology and developmental defects.

摘要

初级纤毛是协调多种感觉和信号活动的细胞附属物。它们对于哺乳动物的正常发育、成体组织稳态、视觉和嗅觉检测至关重要,其功能障碍会导致疾病病理和发育缺陷。