Melander Roberta J, Melander Christian
Department of Chemistry, North Carolina State University, Raleigh, NC 27695, USA.
Department of Chemistry, North Carolina State University, Raleigh, NC 27695, USA.
Chem Biol. 2015 Apr 23;22(4):436-437. doi: 10.1016/j.chembiol.2015.04.005.
Rising antibiotic resistance means that alternative antibacterial strategies are sorely needed. In this issue, Zhu et al. (2015) report the use of a Caenorhabditis elegans model to validate the Pseudomonas aeruginosa virulence factor LasB as a potential therapeutic target and to identify a LasB inhibitor with in vivo efficacy.
抗生素耐药性不断上升意味着迫切需要替代抗菌策略。在本期中，朱等人（2015年）报告了使用秀丽隐杆线虫模型来验证铜绿假单胞菌毒力因子LasB作为潜在治疗靶点，并鉴定一种具有体内疗效的LasB抑制剂。
