HBeAg阴性慢性HBV感染中血清定量HBsAg、ALT与HBV DNA水平之间的关系。

Relation between serum quantitative HBsAg, ALT and HBV DNA levels in HBeAg negative chronic HBV infection.

作者信息

Günal Özgür, Barut Şener, Etikan İlker, Duygu Fazilet, Tuncel Umut, Sünbül Mustafa

机构信息

Department of Infectious Diseases and Clinical Microbiology, Gaziosmanpaşa Universtiy Faculty of Medicine, Tokat, Turkey.

出版信息

Turk J Gastroenterol. 2014 Dec;25 Suppl 1:142-6. doi: 10.5152/tjg.2014.5711.

DOI:10.5152/tjg.2014.5711

PMID:25910293

Abstract

BACKGROUND/AIMS: In this study, we aimed to investigate whether quantitative HBsAg and alanine aminotransferase (ALT) levels correlated with Hepatitis B Virus (HBV) DNA levels in patients with HBeAg negative chronic HBV infection.

MATERIALS AND METHODS

Ninetynine patients were divided into two groups; inactive HBsAg carriers (IC) and active carriers (AC) with HBV DNA>2000 IU/mL. These two groups were compared in terms of ALT and HBsAg levels. Quantitative HBsAg measurements were performed with Elecsys HBsAg II Quant assay (Roche Diagnostic).

RESULTS

Mean age of patients was 43.11±14.79 years. HBsAg and ALT values of IC and AC patients were 2.47±1.35 log10 IU/mL, 3.59±0.97 log10 IU/mL (p=0.0001), and 25.94±13.06 IU/mL, 55.54±82.38 IU/mL (p=0.015), respectively and the difference was significant. When ROC analysis was performed to determine the most appropriate quantitative HBsAg value to define inactive carrier patients, the area under the ROC curve for HBsAg was 0.738 (95% CI:0.637-0.840). A cut-off of 2147 IU/mL revealed sensitivity of 76% and specificity of 70% for diagnosing the IC. Also, a significant correlation was also found between levels of HBV DNA (log) and HBsAg (log) (r: 0.503, p=0.0001).

CONCLUSION

It has been concluded that quantitative measurements of HBsAg could be used to differentiate between IC and AC patients.

摘要

背景/目的：在本研究中，我们旨在调查HBeAg阴性慢性乙型肝炎病毒（HBV）感染患者的HBsAg定量水平和丙氨酸氨基转移酶（ALT）水平是否与HBV DNA水平相关。

材料与方法

99例患者分为两组；HBsAg非活动携带者（IC）和HBV DNA>2000 IU/mL的活动携带者（AC）。比较这两组患者的ALT和HBsAg水平。使用Elecsys HBsAg II Quant检测法（罗氏诊断）进行HBsAg定量检测。

结果

患者的平均年龄为43.11±14.79岁。IC组和AC组患者的HBsAg值分别为2.47±1.35 log10 IU/mL、3.59±0.97 log10 IU/mL（p = 0.0001），ALT值分别为25.94±13.06 IU/mL、55.54±82.38 IU/mL（p = 0.015），差异具有统计学意义。在进行ROC分析以确定定义非活动携带者患者的最合适HBsAg定量值时，HBsAg的ROC曲线下面积为0.738（95%CI：0.637 - 0.840）。2147 IU/mL的临界值诊断IC的敏感性为76%，特异性为70%。此外，还发现HBV DNA（对数）水平与HBsAg（对数）水平之间存在显著相关性（r：0.503，p = 0.0001）。