Liu Hui-Qiang, Wang Yong-Hong, Wang Lan-Lan, Hao Min
Department of Obstetrics and Gynecology, The Second Hospital of Shanxi Medical University, Taiyuan 030001, PR China.
Department of Obstetrics and Gynecology, The Second Hospital of Shanxi Medical University, Taiyuan 030001, PR China.
Exp Mol Pathol. 2015 Aug;99(1):44-9. doi: 10.1016/j.yexmp.2015.04.004. Epub 2015 Apr 21.
To explore the the correlations of p16INK4A (p16) and survivin expressions with cervical intraepithelial neoplasia (CIN) and cervical squamous cell carcinoma.
The p16 and survivin expressions were detected in 50 cervical squamous cell carcinoma tissues, 150 various grades of CIN tissues and 30 normal cervical tissues using immunohistochemistry. All data were analyzed applying SPSS 17.0 software.
The p16 and survivin expressions showed the presence of statistical significance in cervical cancer, CINI, CINII, CINIII and normal cervical tissues (P<0.05), and the comparison also revealed statistical significance among groups (all P<0.05); the p16 and survivin expressions were positively correlated with the grade of cervical diseases (both P<0.05). Moreover, p16 protein was associated with CIN grade and lymph node metastases in cervical cancer (all P<0.05); survivin protein was also related with clinical stages, CIN grade and lymph node metastases (all P<0.05); the p16 and survivin expressions were positively correlated with cervical cancer (r=0.854, P<0.001), and associated with poor prognosis of cervical cancer.
Briefly, p16 and survivin expression may be correlated with the clinico-pathological and prognosis of cervical cancer.
探讨p16INK4A（p16）和生存素表达与宫颈上皮内瘤变（CIN）及宫颈鳞状细胞癌的相关性。
采用免疫组织化学法检测50例宫颈鳞状细胞癌组织、150例不同级别CIN组织及30例正常宫颈组织中p16和生存素的表达。应用SPSS 17.0软件对所有数据进行分析。
p16和生存素表达在宫颈癌、CINI、CINII、CINIII及正常宫颈组织中差异有统计学意义（P<0.05），组间比较差异也有统计学意义（均P<0.05）；p16和生存素表达与宫颈疾病分级呈正相关（均P<0.05）。此外，p16蛋白与宫颈癌的CIN分级及淋巴结转移有关（均P<0.05）；生存素蛋白也与临床分期、CIN分级及淋巴结转移有关（均P<0.05）；p16和生存素表达与宫颈癌呈正相关（r=0.854，P<0.001），且与宫颈癌预后不良有关。
简而言之，p16和生存素表达可能与宫颈癌的临床病理及预后相关。
Zotero 插件