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印度尼西亚精神分裂症住院精神科患者中的代谢综合征

Metabolic syndrome among psychiatric inpatients with schizophrenia in Indonesia.

作者信息

Marthoenis Marthoenis, Aichberger Marion C, Puteh Ibrahim, Syahrial Syahrial, Schouler-Ocak Meryam

机构信息

University Psychiatric Clinic of Charité at St. Hedwig's Hospital, Berlin, Germany.

Departments of Psychiatry and Psychotherapy, Charité University Clinic, Berlin, Germany.

出版信息

Asian J Psychiatr. 2015 Jun;15:10-4. doi: 10.1016/j.ajp.2015.04.004. Epub 2015 Apr 10.

DOI:10.1016/j.ajp.2015.04.004
PMID:25910596
Abstract

Despite the fact that antipsychotic medication increases the risk of metabolic syndrome (MetS), the rate of MetS among psychiatric patients in Indonesia is rarely reported. This study aimed to investigate the prevalence of MetS among inpatients with schizophrenia in Indonesia. Eighty-six hospitalised psychiatric patients with schizophrenia were randomly recruited, and underwent physical examination including a blood test. MetS was assessed based on the International Diabetes Federation (IDF) criteria for South Asia. Among the sample, only eight patients (9.3%) met the IDF criteria for MetS. Women have a higher rate of MetS than men (23.8% vs 4.6%; p=0.02). Reduced high-density lipoprotein (HDL) cholesterol was the most frequent (81.4%) metabolic abnormality among them, followed by central obesity (29.1%), raised triglycerides (23.3%), raised fasting plasma glucose (12.8%), and raised blood pressure (10.5%). Among the various antipsychotics, no differences in MetS prevalence were observed in this population. The rate of MetS among the psychiatric inpatients in this study is lower compared both to the previously reported rate in the general population and to the findings among psychiatric patients with schizophrenia in developed countries. Several factors related to the reduced rate of MetS in this psychiatric inpatient population will be discussed.

摘要

尽管抗精神病药物会增加代谢综合征(MetS)的风险,但印度尼西亚精神科患者中代谢综合征的发生率鲜有报道。本研究旨在调查印度尼西亚精神分裂症住院患者中代谢综合征的患病率。随机招募了86名住院的精神分裂症患者,并对其进行了包括血液检查在内的体格检查。根据国际糖尿病联盟(IDF)针对南亚地区的标准评估代谢综合征。在样本中,只有8名患者(9.3%)符合代谢综合征的IDF标准。女性代谢综合征的发生率高于男性(23.8%对4.6%;p=0.02)。高密度脂蛋白(HDL)胆固醇降低是其中最常见的(81.4%)代谢异常,其次是中心性肥胖(29.1%)、甘油三酯升高(23.3%)、空腹血糖升高(12.8%)和血压升高(10.5%)。在各种抗精神病药物中,该人群中代谢综合征的患病率未观察到差异。本研究中精神科住院患者的代谢综合征发生率与之前报道的普通人群发生率以及发达国家精神分裂症患者的研究结果相比均较低。将讨论与该精神科住院患者人群中代谢综合征发生率降低相关的几个因素。

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