Dialla Pegdwende Olivia, Chu Wai-On, Roignot Patrick, Bone-Lepinoy Marie-Christine, Poillot Marie-Laure, Coutant Charles, Arveux Patrick, Dabakuyo-Yonli Tienhan Sandrine
Breast and Gynaecologic Cancer Registry of Côte d'Or, Centre Georges François Leclerc Comprehensive Cancer Centre, 1 rue Professeur Marion BP 77980, 21079 Dijon Cedex, France; EA 4184, Faculty of Medicine, University of Burgundy, Dijon, France.
Pathology Centre, 33 rue Nicolas Bornier, 21000 Dijon, France.
Maturitas. 2015 Jul;81(3):362-70. doi: 10.1016/j.maturitas.2015.03.025. Epub 2015 Apr 8.
The main purpose of this study was to identify age-related socioeconomic and clinical determinants of quality of life among breast cancer survivors five years after the diagnosis. The secondary objective was to describe quality of life in the studied population according to age.
A cross-sectional survey in five-year breast cancer survivors was conducted in women diagnosed with breast cancer in 2007 and 2008 in Côte d'Or.
Quality of life was assessed with the SF-12, the EORTC-QLQ-C30 and the EORTC-QLQ-BR23 questionnaires. Socio-economic deprivation was assessed by the EPICES questionnaire. Social support was assessed by the Sarason questionnaire and clinical features were collected through the Côte d'Or breast cancer registry. Age-related determinants of quality of life were identified using multivariate mixed model analysis for each SF-12 dimension.
Overall 396 women completed the questionnaires. Women aged <65 years had a better quality of life and a greater availability of social support than did women aged ≥65 years. Body mass index, relapse and EPICES were found to be determinants of quality of life in younger women (p<0.006). For older women, comorbidities and EPICES deprivation scores were predictors of low quality of life scores (p<0.006).
Five years after breast cancer diagnosis, disease severity did not affect quality of life. The major determinants of quality of life in younger women were disease relapse and EPICES deprivation scores while those in older women were comorbidities and EPICES deprivation scores.
本研究的主要目的是确定乳腺癌幸存者在确诊五年后与年龄相关的社会经济和临床生活质量决定因素。次要目的是根据年龄描述所研究人群的生活质量。
对2007年和2008年在科多尔省被诊断为乳腺癌的女性进行了一项针对乳腺癌幸存者五年后的横断面调查。
使用SF-12、欧洲癌症研究与治疗组织生活质量核心问卷（EORTC-QLQ-C30）和欧洲癌症研究与治疗组织乳腺癌特异性问卷（EORTC-QLQ-BR23）对生活质量进行评估。通过EPICES问卷评估社会经济剥夺情况。通过萨拉森问卷评估社会支持情况，并通过科多尔省乳腺癌登记处收集临床特征。使用多变量混合模型分析每个SF-12维度来确定与年龄相关的生活质量决定因素。
共有396名女性完成了问卷调查。年龄<65岁的女性比年龄≥65岁的女性生活质量更好，社会支持也更多。体重指数、复发和EPICES被发现是年轻女性生活质量的决定因素（p<0.006）。对于老年女性，合并症和EPICES剥夺分数是生活质量得分低的预测因素（p<0.006）。
乳腺癌诊断五年后，疾病严重程度并未影响生活质量。年轻女性生活质量的主要决定因素是疾病复发和EPICES剥夺分数，而老年女性的主要决定因素是合并症和EPICES剥夺分数。
