子宫内膜癌或卵巢癌老年患者的长期生活质量和性功能
Long-term quality of life and sexual function of elderly people with endometrial or ovarian cancer.
作者信息
Mamguem Kamga Ariane, Bengrine-Lefevre Leila, Quipourt Valérie, Favier Laure, Darut-Jouve Ariane, Marilier Sophie, Arveux Patrick, Desmoulins Isabelle, Dabakuyo-Yonli Tienhan Sandrine
机构信息
Epidemiology and Quality of Life Research Unit, Lipids, Nutrition, Cancer Research Center, INSERM U1231, Georges Francois Leclerc Centre - UNICANCER, 1 rue Professeur Marion, BP 77980, 21079, Dijon Cedex, France.
Medical Oncology Department, Centre Georges-François Leclerc, 1 rue Pr. Marion, 21000, Dijon, France.
出版信息
Health Qual Life Outcomes. 2021 Feb 12;19(1):56. doi: 10.1186/s12955-021-01675-2.
BACKGROUND
With the growing number of older endometrial cancer (EC) and ovarian cancer (OC) survivors, data on long-term health-related quality of life (HRQoL) became an important issue in the management of older patients. So, the aim of this study was to describe and compare according to age long-term HRQoL, sexual function, and social deprivation of adults with either EC or OC.
METHODS
A cross-sectional study was set up using data from the Côte d'Or gynecological cancer registry. A series of questionnaires assessing HRQoL (SF-12), sexual function (FSFI), anxiety/depression (HADS), social support (SSQ6) and deprivation (EPICES) were offered to women with EC or OC diagnosed between 2006 and 2013. HRQoL, sexual function, anxiety/depression, social support and deprivation scores were generated and compared according to age (< 70 years and ≥ 70 years).
RESULTS
A total of 145 women with EC (N = 103) and OC (N = 42) participated in this study. Fifty-six percent and 38% of EC and OC survivors respectively were aged 70 and over. Treatment did not differ according to age either in OC or EC. The deprivation level did not differ between older and younger survivors with OC while older survivors with EC were more precarious. The physical HRQoL was more altered in older EC survivors. This deterioration concerned only physical functioning (MD = 24, p = 0.012) for OC survivors while it concerned physical functioning (MD = 30, p < 0.0001), role physical (MD = 22, p = 0.001) and bodily pain (MD = 21, p = 0.001) for EC survivors. Global health (MD = 11, p = 0.011) and role emotional (MD = 12, p = 0.018) were also deteriorated in elderly EC survivors. Sexual function was deteriorated regardless of age and cancer location with a more pronounced deterioration in elderly EC survivors for desire (p = 0.005), arousal (p = 0.015) and orgasm (p = 0.007). Social support, anxiety and depression were not affected by age regardless of location.
CONCLUSION
An average 6 years after diagnosis, the impact of cancer on HRQoL is greatest in elderly survivors with either EC or OC.
背景
随着老年子宫内膜癌（EC）和卵巢癌（OC）幸存者数量的增加，与长期健康相关的生活质量（HRQoL）数据成为老年患者管理中的一个重要问题。因此，本研究的目的是根据年龄描述和比较患有EC或OC的成年人的长期HRQoL、性功能和社会剥夺情况。
方法
利用科多尔省妇科癌症登记处的数据进行了一项横断面研究。向2006年至2013年期间诊断为EC或OC的女性提供了一系列评估HRQoL（SF - 12）、性功能（FSFI）、焦虑/抑郁（HADS）、社会支持（SSQ6）和剥夺（EPICES）的问卷。根据年龄（<70岁和≥70岁）生成并比较HRQoL、性功能、焦虑/抑郁、社会支持和剥夺得分。
结果
共有145例患有EC（N = 103）和OC（N = 42）的女性参与了本研究。EC和OC幸存者中分别有56%和38%的年龄在70岁及以上。OC和EC患者的治疗在年龄方面没有差异。OC的老年和年轻幸存者之间的剥夺水平没有差异，而EC的老年幸存者情况更不稳定。老年EC幸存者的身体HRQoL改变更大。对于OC幸存者，这种恶化仅涉及身体功能（MD = 24，p = 0.012），而对于EC幸存者，它涉及身体功能（MD = 30，p < 0.0001）、角色身体（MD = 22，p = 0.001）和身体疼痛（MD = 21，p = 0.001）。老年EC幸存者的总体健康（MD = 11，p = 0.011）和角色情感（MD = 12，p = 0.018）也有所恶化。无论年龄和癌症部位如何，性功能都会恶化，老年EC幸存者在性欲（p = 0.005）、性唤起（p = 0.015）和性高潮（p = 0.007）方面的恶化更为明显。无论癌症部位如何，社会支持、焦虑和抑郁均不受年龄影响。
结论
在诊断后平均6年，癌症对HRQoL的影响在患有EC或OC的老年幸存者中最为显著。
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