Livzan M A, Lapteva I V, Miller T S
Eksp Klin Gastroenterol. 2014(8):27-33.
To study the impact of leptin and leptinresistance on formation of non-alcoholic fatty liver disease (NAFLD) of people with obesity and overweight.
105 patients with obesity and overweight were examined, among them 19 men and 86 women, median age 58 (50-63) years. Risk factors development NAFLD, anthropometric indices, biochemical analysis of blood, abdominal ultrasonic studies, levels leptin and its soluble receptor were estimated. examined people with NAFLD were included into 2 groups: main group (patients NAFLD, n = 77) and comparison group (n = 28).
Waist volume, body mass index, blood glucose were higher in group of patients with NAFLD (p < 0.0001, p < 0.003, p < 0.00002, level) and had positive connection with the change in liver development (rs = (0.376), p < 0.00008, rs = (0.293), p < 0.002, rs = (0.417), p < 0.00001, level). Leptin has direct dependence (rs = (0.291), p < 0.027), while level of soluble receptors to leptin was of reverse dependence (rs = (-0.456), p < 0.0003) on the degree of body weight. Between these indicators in the group with obesity and overweight negative correlation of moderate strength (rs = (-0.370), p < 0.004) was revealed. There were tendencies to a higher level leptin and lower level receptor to leptin in group with NAFLD (median level leptin 29.20 (12.63-44.98) in main group against 27.49 (12.05-54.79), median receptor to leptin 18.25 (14.69-24.26) against 22.05 (14.57-32.04), respectively). However these indicators in the main group also had a negative correlation bond of moderate strength (rs = (-0.384), p < 0.007).
Development of NAFLD are associated with obesity and excess body weight, phenomenon of leptinresistance arises to patients with obesity and can be considered as predictor of the development and progression of NAFLD among this category of patients.
研究瘦素及瘦素抵抗对肥胖和超重人群非酒精性脂肪性肝病（NAFLD）形成的影响。
对105例肥胖和超重患者进行检查，其中男性19例，女性86例，年龄中位数为58（50 - 63）岁。评估NAFLD的危险因素、人体测量指标、血液生化分析、腹部超声检查、瘦素及其可溶性受体水平。将患有NAFLD的受检者分为2组：主要组（NAFLD患者，n = 77）和对照组（n = 28）。
NAFLD患者组的腰围、体重指数、血糖更高（p < 0.0001，p < 0.003，p < 0.00002水平），且与肝脏病变的变化呈正相关（rs = (0.376)，p < 0.00008，rs = (0.293)，p < 0.002，rs = (0.417)，p < 0.00001水平）。瘦素具有直接相关性（rs = (0.291)，p < 0.027），而瘦素可溶性受体水平与体重程度呈负相关（rs = (-0.456)，p < 0.0003）。在肥胖和超重组中，这些指标之间显示出中等强度的负相关（rs = (-0.370)，p < 0.004）。NAFLD组有瘦素水平较高和瘦素受体水平较低的趋势（主要组瘦素中位数水平为29.20（12.63 - 44.98），而对照组为27.49（12.05 - 54.79）；主要组瘦素受体中位数为18.25（14.69 - 24.26），而对照组为22.05（14.57 - 32.04））。然而，主要组中的这些指标也具有中等强度的负相关关系（rs = (-0.384)，p < 0.007）。
NAFLD的发生与肥胖和体重超标有关，肥胖患者会出现瘦素抵抗现象，可将其视为这类患者中NAFLD发生和进展的预测指标。
