Sayın Oya, Tokgöz Yavuz, Arslan Nur
J Pediatr Endocrinol Metab. 2014 May;27(5-6):479-84. doi: 10.1515/jpem-2013-0296.
Nonalcoholic fatty liver disease (NAFLD) is the accumulation of excess fat in the liver in the absence of alcohol consumption, which is commonly associated with obesity and increased risk of atherosclerosis as well as insulin resistance. Adropin is a recently identified protein encoded by the gene related with energy homeostasis, which is expressed in the liver and the brain and has a role in preventing insulin resistance and obesity. The aim of this study was to investigate the serum adropin and leptin levels in obese adolescents and compare the patients with, and without, NAFLD and with healthy controls.
Sixty-four obese adolescents (30 with NAFLD, 34 without NAFLD) and 36 healthy controls were enrolled in the study. Serum adropin and leptin levels were evaluated by sandwich enzyme-linked immunosorbent assay.
Serum adropin levels were significantly lower in obese children than healthy controls (3.2±1.0 and 9.2±1.2 ng/mL, respectively, p=0.001). Serum leptin levels were significantly higher in patients than in controls (12.4±1.1 and 4.1±3.1 pg/mL, respectively; p=0.000). Serum adropin levels of patients with NAFLD were significantly lower than in patients without NAFLD (2.9±0.5 and 3.5±1.2 ng/mL, respectively; p=0.023) and healthy controls (p=0.000). Logistic regression analysis showed that a decrease in adropin levels was the only independent factor for fatty liver disease in obese adolescents (odds ratio: 3.07, 95% confidence interval 1.14-8.2, p=0.026). Leptin, relative weight and HOMA-IR of the patients were not independent risk factors for NAFLD.
In this study, serum adropin levels were significantly lower in obese adolescents with fatty liver disease compared to patients without fatty liver disease and healthy controls. Lower adropin level was an independent risk factor for NAFLD in obese adolescents in logistic regression analysis. Assessment of serum adropin concentrations may provide a reliable indicator of fatty liver disease in obese adolescents.
非酒精性脂肪性肝病（NAFLD）是指在无酒精摄入情况下肝脏中脂肪过度蓄积，通常与肥胖、动脉粥样硬化风险增加以及胰岛素抵抗相关。Adropin是一种最近发现的由与能量稳态相关基因编码的蛋白质，在肝脏和大脑中表达，对预防胰岛素抵抗和肥胖具有作用。本研究旨在调查肥胖青少年的血清Adropin和瘦素水平，并比较患有和未患有NAFLD的患者以及健康对照者。
64名肥胖青少年（30名患有NAFLD，34名未患有NAFLD）和36名健康对照者纳入本研究。采用夹心酶联免疫吸附测定法评估血清Adropin和瘦素水平。
肥胖儿童的血清Adropin水平显著低于健康对照者（分别为3.2±1.0和9.2±1.2 ng/mL，p=0.001）。患者的血清瘦素水平显著高于对照者（分别为12.4±1.1和4.1±3.1 pg/mL；p=0.000）。患有NAFLD的患者血清Adropin水平显著低于未患有NAFLD的患者（分别为2.9±0.5和3.5±1.2 ng/mL；p=0.023）以及健康对照者（p=0.000）。逻辑回归分析显示，Adropin水平降低是肥胖青少年患脂肪性肝病的唯一独立因素（比值比：3.07，95%置信区间1.14 - 8.2，p=0.026）。患者的瘦素、相对体重和HOMA-IR并非NAFLD的独立危险因素。
在本研究中，与未患脂肪性肝病的患者及健康对照者相比，患有脂肪性肝病的肥胖青少年血清Adropin水平显著降低。在逻辑回归分析中，较低的Adropin水平是肥胖青少年患NAFLD的独立危险因素。评估血清Adropin浓度可能为肥胖青少年脂肪性肝病提供可靠指标。
