感染、全身炎症与阿尔茨海默病。

Infection, systemic inflammation, and Alzheimer's disease.

作者信息

Lim Siok Lam, Rodriguez-Ortiz Carlos J, Kitazawa Masashi

机构信息

Department of Molecular and Cell Biology, School of Natural Sciences, University of California, Merced, 5200 North Lake Road, Merced, CA 95343, USA.

出版信息

Microbes Infect. 2015 Aug;17(8):549-56. doi: 10.1016/j.micinf.2015.04.004. Epub 2015 Apr 22.

DOI:10.1016/j.micinf.2015.04.004

PMID:25912134

Abstract

Alzheimer's disease (AD) is a leading cause of dementia among elderly. Yet, its etiology remains largely unclear. In this review, we summarize studies that associate systemic infection and neuroinflammation with AD, while highlighting that early-life or life-long exposure to infectious agents predisposes one to develop AD at a later age.

摘要

阿尔茨海默病（AD）是老年人痴呆的主要病因。然而，其病因在很大程度上仍不清楚。在本综述中，我们总结了将全身感染和神经炎症与AD相关联的研究，同时强调早年或终生接触感染因子会使人在晚年易患AD。