Yang Xiaofeng, Li Yanxiang, He Yanhao, Li Tingting, Wang Weirong, Zhang Jiye, Wei Jingyuan, Deng Yanhong, Lin Rong
Department of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an 710061, Shaanxi, PR China.
Laboratory Animal Center, Xi'an Jiaotong University Health Science Center, Xi'an 710061, Shaanxi, PR China.
Int Immunopharmacol. 2015 Jun;26(2):401-8. doi: 10.1016/j.intimp.2015.04.017. Epub 2015 Apr 22.
Cordycepin (Cor), which is a naturally occurring nucleoside derivative isolated from Cordyceps militaris, has been shown to exert excellent antiinflammatory activity in a murine model of acute lung injury. Thus, this study aimed to evaluate the antiasthmatic activity of Cor (10, 20, and 40 mg/kg) and to investigate the possible underlying molecular mechanisms. We found that Cor attenuated airway hyperresponsiveness, mucus hypersecretion, and ovalbumin (Ova)-specific immunoglobulin (Ig) E, and alleviated lung inflammation with decreased eosinophils and macrophages in the bronchoalveolar lavage (BAL) fluid. Notably, Cor reduced the upregulation of eotaxin, intercellular cell adhesion molecule-1 (ICAM-1), IL-4, IL-5, and IL-13 in the BAL fluid. Furthermore, Cor markedly blocked p38-MAPK and nuclear factor-kappaB (NF-κB) signalling pathway activation in the Ova-driven asthmatic mice. In conclusion, this study demonstrated that some of the antiasthmatic benefits of Cor attributable to diets and/or tonics may result from reductions in inflammatory processes and that these antiasthmatic properties involve the inhibition of Th2-type responses through the suppression of the p38-MAPK and NF-κB signalling pathways.
虫草素（Cor）是从蛹虫草中分离出的一种天然核苷衍生物，已被证明在急性肺损伤小鼠模型中具有出色的抗炎活性。因此，本研究旨在评估虫草素（10、20和40mg/kg）的抗哮喘活性，并探讨其潜在的分子机制。我们发现虫草素减轻了气道高反应性、黏液高分泌和卵清蛋白（Ova）特异性免疫球蛋白（Ig）E，并通过减少支气管肺泡灌洗（BAL）液中的嗜酸性粒细胞和巨噬细胞减轻了肺部炎症。值得注意的是，虫草素降低了BAL液中嗜酸性粒细胞趋化因子、细胞间黏附分子-1（ICAM-1）、白细胞介素-4、白细胞介素-5和白细胞介素-13的上调。此外，虫草素显著阻断了卵清蛋白诱导的哮喘小鼠中p38丝裂原活化蛋白激酶（p38-MAPK）和核因子-κB（NF-κB）信号通路的激活。总之，本研究表明，饮食和/或滋补品中虫草素的一些抗哮喘益处可能源于炎症过程的减少，并且这些抗哮喘特性涉及通过抑制p38-MAPK和NF-κB信号通路来抑制Th2型反应。
