Saxena Juhi, Agarwal Gaurang, Das Sarvjeet, Kumar Anshu, Thakkar Krish, Kaushik Sanket, Srivatsava Vijay Kumar, Siddiqui Arif Jamal, Jyoti Anupam
Department of Biotechnology, Parul Institute of Technology, Parul University, Vadodara, Gujarat, India.
Department of Life Science, Parul Institute of Applied Science, Parul University, Vadodara, Gujarat, India.
Curr Pharm Des. 2025;31(11):823-842. doi: 10.2174/0113816128326301240920040036.
spp. (CS), a well-known medicinal mushroom that belongs to Tibetan medicine and is predominantly found in the high altitudes in the Himalayas. CS is a rich reservoir of various bioactive substances including nucleosides, sterols flavonoids, peptides, and phenolic compounds. The bioactive compounds and CS extract have antibacterial, antioxidant, immunomodulatory, and inflammatory properties in addition to organ protection properties across a range of disease states. The study aimed to review the potential of CS, a medicinal mushroom, as a treatment for sepsis. While current sepsis drugs have side effects, CS shows promise due to its anti-inflammatory, antioxidant, and antibacterial properties. We have performed an extensive literature search based on published original and review articles in Scopus and PubMed. The keywords used were Cordyceps, sepsis, and inflammation. Studies indicate that CS extract and bioactive compounds target free radicals including oxidative as well as nitrosative stress, lower inflammation, and modulate the immune system, all of which are critical components in sepsis. The brain, liver, kidneys, lungs, and heart are among the organs that CS extracts may be able to shield against harm during sepsis. Traditional remedies with anti-inflammatory and protective qualities, such as Cordyceps mushrooms, are promising in sepsis. However, more research including clinical trials is required to validate the usefulness of CS metabolites in terms of organ protection and fight infections in sepsis.
冬虫夏草（CS）是一种著名的药用真菌，属于藏药，主要生长在喜马拉雅山脉的高海拔地区。CS富含多种生物活性物质，包括核苷、甾醇、黄酮类、肽和酚类化合物。除了在一系列疾病状态下具有器官保护特性外，这些生物活性化合物和CS提取物还具有抗菌、抗氧化、免疫调节和抗炎特性。该研究旨在评估药用真菌CS作为脓毒症治疗方法的潜力。虽然目前的脓毒症药物有副作用，但CS因其抗炎、抗氧化和抗菌特性而显示出前景。我们基于Scopus和PubMed上发表的原始文章和综述文章进行了广泛的文献检索。使用的关键词是冬虫夏草、脓毒症和炎症。研究表明，CS提取物和生物活性化合物针对自由基，包括氧化应激和亚硝化应激，降低炎症，并调节免疫系统，所有这些都是脓毒症的关键组成部分。大脑、肝脏、肾脏、肺和心脏是CS提取物在脓毒症期间可能能够保护免受伤害的器官之一。具有抗炎和保护特性的传统药物，如冬虫夏草，在脓毒症治疗中很有前景。然而，需要更多的研究，包括临床试验，来验证CS代谢产物在脓毒症器官保护和抗感染方面的有效性。
