Kitasato I, Niizato T, Inouye S
Research & Development, Meiji Seika Kaisha Ltd., Tokyo, Japan.
Drugs Exp Clin Res. 1989;15(6-7):249-59.
Intramuscular administration of dibekacin or gentamicin to Fischer rats at doses of 10, 20 and 40 mg/kg for 11 days gave polyuria, enzymuria and cytauria. These changes were suppressed completely or partially by the simultaneous administration of glucarolactam sodium or potassium salt. The ameliorating results were supported by serum and histopathological analyses on day 12. A rise in BUN and serum creatinine levels was partially or completely suppressed and histopathological scores were improved by co-administration of glucarolactam salts.
以10、20和40mg/kg的剂量给Fischer大鼠肌肉注射双去氧卡那霉素或庆大霉素，持续11天，会导致多尿、酶尿和细胞尿。同时给予葡萄糖醛酸内酯钠或钾盐可完全或部分抑制这些变化。第12天的血清和组织病理学分析支持了改善结果。联合给予葡萄糖醛酸内酯盐可部分或完全抑制尿素氮和血清肌酐水平的升高，并改善组织病理学评分。
