Piccolomini R, Cellini L, Allocati N, Di Girolamo A, D'Eletto M R, D'Antonio D, Ravagnan G
Institute of Experimental Medicine, Department of Microbiology, University G. D'Annunzio, Chieti, Italy.
Drugs Exp Clin Res. 1989;15(6-7):303-8.
Coagulase-negative staphylococci (CNS) have long been regarded as innocuous skin commensals with little pathogenic potential but they have recently become, under appropriate conditions, an important cause of infections. In fact, infections caused by CNS are an increasing problem especially, but not exclusively, in immuno-compromised patients. A total of 149 strains of CNS were identified from 47 patients admitted to the Haematology Department of Pescara Hospital from October 1986 to November 1987. The strains, isolated from different parts of the body and characterized by their methicillin susceptibility, were classified by API-Staph in 11 different groups. MICs and MBCs of netilmicin alone and combined with azlocillin, mezlocillin and imipenem were studied. For all combinations FIC and FBC indices were determined. The killing kinetics of the drugs mentioned above were also determined. Except for a few microorganisms (less than 5%), the associations showed a synergic or additive effect.
凝固酶阴性葡萄球菌（CNS）长期以来一直被视为无害的皮肤共生菌，致病潜力很小，但最近在适当条件下，它们已成为感染的重要原因。事实上，CNS引起的感染尤其是在免疫功能低下的患者中（但不仅限于此）正成为一个日益严重的问题。1986年10月至1987年11月期间，从佩斯卡拉医院血液科收治的47例患者中总共鉴定出149株CNS。这些菌株从身体不同部位分离出来，并根据其对甲氧西林的敏感性进行了表征，通过API-Staph分类为11个不同的组。研究了奈替米星单独使用以及与阿洛西林、美洛西林和亚胺培南联合使用时的最低抑菌浓度（MIC）和最低杀菌浓度（MBC）。对于所有组合，测定了联合抑菌系数（FIC）和联合杀菌系数（FBC）指数。还测定了上述药物的杀菌动力学。除少数微生物（少于5%）外，这些联合用药显示出协同或相加作用。
