Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, 24 Tongjia Xiang, Gulou District, Nanjing 210009, China.
Nanoscale. 2015 May 21;7(19):8884-97. doi: 10.1039/c5nr00473j.
A polyelectrolyte microcapsule-based, cancer-targeting, and controlled drug delivery system has been developed as a multifunctional theranostic agent for synergistic cancer treatment. This new system, called FA-MC@GNR, is composed of folic acid (FA)-modified, multi-layered, hollow microcapsules loaded with gold nanorods (GNRs), and undergoes thermal degradation under near infrared (NIR) light. Either an NIR dye (MPA) or anti-cancer drug (doxorubicin, DOX) was loaded into the microcapsules via physical adsorption, yielding FA-MC@GNRs/MPA or FA-MC@GNRs/DOX, both of which exhibit no obvious toxicity, high stability, and remarkably improved tumor-targeting capabilities in vivo. Utilizing the strong NIR absorption of FA-MC@GNRs/DOX, we demonstrate the system's ability to simultaneously elicit photothermal therapy and controlled chemotherapy, achieving synergistic cancer treatment both in vitro cellular and in vivo animal experiments. Our study presents a new type of multifunctional micro-carrier for the delivery of chemotherapeutic drugs and photothermal agents, which has been shown to be an effective therapeutic approach for combined cancer treatment.
已开发出一种基于聚电解质微胶囊的、针对癌症的、控释药物输送系统，作为协同癌症治疗的多功能治疗药物。这种新系统称为 FA-MC@GNR，由叶酸（FA）修饰的、多层、空心微胶囊组成，负载金纳米棒（GNR），并在近红外（NIR）光下进行热降解。通过物理吸附将 NIR 染料（MPA）或抗癌药物（阿霉素，DOX）载入微胶囊中，得到 FA-MC@GNRs/MPA 或 FA-MC@GNRs/DOX，两者均无明显毒性、高稳定性，并显著提高了体内肿瘤靶向能力。利用 FA-MC@GNRs/DOX 的强 NIR 吸收，我们证明了该系统同时引发光热治疗和控释化疗的能力，在体外细胞和体内动物实验中均实现了协同癌症治疗。我们的研究提出了一种用于输送化疗药物和光热剂的新型多功能微载体，已被证明是联合癌症治疗的有效治疗方法。
