Datta Suvro Sankha, Reddy Mahua, Basu Sabita
Department of Transfusion Medicine, Tata Medical Center, Newtown, Rajarhat, Kolkata, West Bengal, India.
Department of Transfusion Medicine, Tata Medical Center, Newtown, Rajarhat, Kolkata, West Bengal, India.
Transfus Apher Sci. 2015 Oct;53(2):205-7. doi: 10.1016/j.transci.2015.03.018. Epub 2015 Apr 14.
A 12-year-old male child presented to the emergency room with three days history of cola-colored urine, mild icterus, dyspnea, palpitation and fatigue. He had a history of chronic ITP two years ago and had since been on steroid for maintenance of platelet count. He was subsequently diagnosed as a case of warm autoimmune hemolytic anemia. Laboratory investigations were suggestive of intravascular hemolysis, and on immuno-hematological evaluation it was diagnosed that the patient had autoantibody with mimicking anti-e specificity. The specificity of autoantibody was further confirmed by adsorption study. The patient was successfully managed by transfusion of Rh(e)-negative red cells,steroid and rituximab therapy. So an autoantibody with mimicking anti-e specificity was identified in this case, which was significant in clinical point of view.
一名12岁男童因出现可乐色尿、轻度黄疸、呼吸困难、心悸和疲劳三天而就诊于急诊室。他两年前有慢性免疫性血小板减少症病史，此后一直在使用类固醇维持血小板计数。随后他被诊断为温抗体型自身免疫性溶血性贫血。实验室检查提示血管内溶血，免疫血液学评估诊断该患者具有模拟抗 - e特异性的自身抗体。通过吸附研究进一步证实了自身抗体的特异性。该患者通过输注Rh(e)阴性红细胞、类固醇和利妥昔单抗治疗成功得到管理。因此，本病例中鉴定出一种具有模拟抗 - e特异性的自身抗体，从临床角度来看具有重要意义。
