中国安徽省马鞍山市孕妇细菌性阴道病的发病率及危险因素：一项前瞻性研究

Incidence and risk factors of bacterial vaginosis among pregnant women: a prospective study in Maanshan city, Anhui Province, China.

作者信息

Li Xiu-De, Tong Fei, Zhang Xiu-Jun, Pan Wei-Jun, Chen Mao-Lin, Wang Cheng-Cheng, Li Xiang, Gao Guo-Peng, Sun Liang, Sun Ye-Huan

机构信息

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, People's Republic of China.

Department of Obstetrics and Gynaecology, Maternal and Child Health Care Hospital of Maanshan, Maanshan, Anhui, People's Republic of China.

出版信息

J Obstet Gynaecol Res. 2015 Aug;41(8):1214-22. doi: 10.1111/jog.12704. Epub 2015 Apr 27.

DOI:10.1111/jog.12704

PMID:25913643

Abstract

AIM

The aim of this study was to identify the incidence and risk factors of bacterial vaginosis among pregnant women.

MATERIAL AND METHODS

Prospective data from a cohort of 668 pregnant women were used to identify potential risk factors for bacterial vaginosis during pregnancy by Cox proportional hazards regression.

RESULTS

A total of 204 incident cases of bacterial vaginosis were diagnosed in 274.8 woman-years of follow-up. The bacterial vaginosis incidence rate was 0.74 per 1 woman-year and median prevalence during follow-up was 15.6%. In the adjusted model, changing underwear nearly everyday, miscarriage history, urinary tract infection during follow-up, husbands' education level, and concurrent trichomoniasis and candidiasis remained significantly associated with bacterial vaginosis (adjusted hazard ratio and 95% confidence interval were 1.87 [1.26-2.77]; 2.96 [1.96-4.47]; 2.41 [1.05-5.49]; 0.50 [0.32-0.77]; 1.82 [1.02-3.25]; 1.88 [1.30-2.70], respectively).

CONCLUSION

Bacterial vaginosis during pregnancy can be affected by many factors, and some are indirectly acting factors. Further prospective studies that include a larger sample size and more information on the development of bacterial vaginosis are needed.

摘要

目的

本研究旨在确定孕妇细菌性阴道病的发病率及危险因素。

材料与方法

采用来自668名孕妇队列的前瞻性数据，通过Cox比例风险回归分析确定孕期细菌性阴道病的潜在危险因素。

结果

在274.8人年的随访中，共诊断出204例细菌性阴道病发病病例。细菌性阴道病发病率为每1人年0.74例，随访期间的中位患病率为15.6%。在调整模型中，几乎每天更换内衣、流产史、随访期间的尿路感染、丈夫的教育水平以及同时合并滴虫病和念珠菌病仍与细菌性阴道病显著相关（调整后的风险比及95%置信区间分别为1.87 [1.26 - 2.77]；2.96 [1.96 - 4.47]；2.41 [1.05 - 5.49]；0.50 [0.32 - 0.77]；1.82 [1.02 - 3.25]；1.88 [1.30 - 2.70]）。