Tronel Sophie, Charrier Vanessa, Sage Cyrille, Maitre Marlene, Leste-Lasserre Thierry, Abrous Djoher N
Neurocentre MagendiePhysiopathologie De La Plasticité NeuronaleUnité 862, Institut National De La Santé Et De La Recherche Médicale, Inserm U862, Bordeaux-F33077, Paris, France.
Université Bordeaux, Bordeaux-F33000, France.
Hippocampus. 2015 Nov;25(11):1472-9. doi: 10.1002/hipo.22468. Epub 2015 May 13.
Adult neurogenesis occurs in the dentate gyrus (DG) of the hippocampus, which is a key structure in learning and memory. Adult-generated granule cells have been shown to play a role in spatial memory processes such as acquisition or retrieval, in particular during an immature stage when they exhibit a period of increased plasticity. Here, we demonstrate that immature and mature neurons born in the DG of adult rats are similarly activated in spatial memory processes. By imaging the activation of these two different neuron generations in the same rat and by using the immediate early gene Zif268, we show that these neurons are involved in both spatial memory acquisition and retrieval. These results demonstrate that adult-generated granule cells are involved in memory beyond their immaturity stage.
成体神经发生发生在海马体的齿状回（DG），海马体是学习和记忆的关键结构。已证明成体产生的颗粒细胞在空间记忆过程如获取或检索中发挥作用，特别是在它们表现出可塑性增加时期的不成熟阶段。在这里，我们证明成年大鼠齿状回中产生的未成熟和成熟神经元在空间记忆过程中同样被激活。通过对同一只大鼠中这两种不同代神经元的激活进行成像，并使用即早基因Zif268，我们表明这些神经元参与空间记忆的获取和检索。这些结果表明，成体产生的颗粒细胞在其不成熟阶段之后仍参与记忆。
