Department of Organic Chemistry, Weizmann Institute of Science, Rehovot, 76100 (Israel).
Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781039, Assam (India).
Angew Chem Int Ed Engl. 2015 Oct 12;54(42):12357-60. doi: 10.1002/anie.201502418. Epub 2015 Apr 27.
The atom-efficient and environmentally benign catalytic hydrogenation of carboxylic acid esters to alcohols has been accomplished in recent years mainly with precious-metal-based catalysts, with few exceptions. Presented here is the first cobalt-catalyzed hydrogenation of esters to the corresponding alcohols. Unexpectedly, the evidence indicates the unprecedented involvement of ester enolate intermediates.
近年来，主要使用贵金属基催化剂实现了羧酸酯的高效、环境友好催化氢化转化为醇，鲜有例外。本文首次报道了酯的钴催化氢化反应，得到相应的醇。令人意外的是，实验证据表明酯烯醇化物中间体的前所未有的参与。
