Physical Biosciences Division, Materials Sciences Division and Synthetic Biology Institute, Lawrence Berkeley National Laboratory, 1 Cyclotron Rd. Mail Stop 67R5115, Berkeley, CA, 94720, USA.
Biology and Biotechnology Division, Lawrence Livermore National Laboratory, Mail Stop L-179, 7000 East Ave, Livermore, CA, 94550, USA.
Adv Mater. 2015 Oct 14;27(38):5797-804. doi: 10.1002/adma.201500344. Epub 2015 Apr 27.
Critical biological processes such as energy generation and signal transduction are driven by the flow of electrons and ions across the membranes of living cells. As a result, there is substantial interest in creating nanostructured materials that control transport of these charged species across biomembranes. Recent advances in the synthesis of de novo and protein nanostructures for transmembrane ion and electron transport and the mechanistic understanding underlying this transport are described. This body of work highlights the promise such nanostructures hold for directing transmembrane transport of charged species as well as challenges that must be overcome to realize that potential.
关键的生物过程，如能量产生和信号转导，是由电子和离子在活细胞的膜上流动驱动的。因此，人们有很大的兴趣创造控制这些带电物质跨生物膜运输的纳米结构材料。本文描述了用于跨膜离子和电子传输的从头合成和蛋白质纳米结构的最新进展，以及这种传输的基础机制理解。这项工作强调了这些纳米结构在引导带电物质跨膜运输方面的潜力，以及为实现这一潜力必须克服的挑战。
