Meier W, Eiermann W, Stieber P, Schneider A, Fateh-Moghadam A, Hepp H
Department of Obstetrics and Gynecology, Klinikum Grosshadern, Ludwig-Maximilians-University Munich, F.R.G.
Eur J Cancer Clin Oncol. 1989 Nov;25(11):1555-9. doi: 10.1016/0277-5379(89)90297-6.
Squamous cell carcinoma (SCC) antigen was first described by Kato et al. in patients with carcinoma of the cervix uteri. SCC serum levels can be measured with a radioimmunoassay. In our investigation, 2.0 ng/ml was taken as the upper limit of the standard range. In 35 healthy women there were no elevated SCC serum levels. Eight of 40 patients with breast, endometrial and ovarian cancer had raised SCC levels. In only two of 12 patients with benign gynecological diseases, SCC was also elevated. Sixty per cent of the patients with primary and 73% of the patients with recurrent cervical cancer showed pathological values; CEA was elevated in 31% and 51% respectively. The absolute values increased with the stage of the disease. Sixty-nine per cent of patients with squamous cell carcinoma had elevated levels. In five of nine adenosquamous carcinomas SCC was pathological. SCC shows a high sensitivity for squamous cell carcinomas of the cervix uteri. The tumor marker might be helpful in the control of primary therapy and follow-up of cervical cancer patients.
鳞状细胞癌（SCC）抗原最初由加藤等人在子宫颈癌患者中发现。SCC血清水平可用放射免疫测定法测量。在我们的研究中，2.0 ng/ml被视为标准范围的上限。35名健康女性的SCC血清水平均未升高。40名乳腺癌、子宫内膜癌和卵巢癌患者中有8人的SCC水平升高。12名良性妇科疾病患者中只有2人的SCC水平也升高。原发性宫颈癌患者中有60%、复发性宫颈癌患者中有73%的SCC值呈病理性升高；癌胚抗原（CEA）水平分别在31%和51%的患者中升高。绝对值随疾病分期增加。69%的鳞状细胞癌患者水平升高。9例腺鳞癌中有5例SCC值呈病理性升高。SCC对子宫颈鳞状细胞癌具有较高的敏感性。该肿瘤标志物可能有助于宫颈癌患者的初始治疗监测和随访。
