Meier W, Eiermann W, Stieber P, Fateh-Moghadam A, Hepp H
Frauenklinik und Institut für Klinische Chemie, Ludwig-Maximilians-Universität, München.
Geburtshilfe Frauenheilkd. 1989 Jul;49(7):625-9. doi: 10.1055/s-2008-1026667.
Squamous cell carcinoma (SCC) antigen was first described 1977 by Kato et al. in patients with carcinoma of the cervix uteri. SCC serum levels can be measured with a radioimmunoassay (Abbott), in our investigation 2.0 ng/ml were taken as the upper limit of the standard range. In 35 healthy women there were no elevated SCC serum levels. In only 2 of 50 patients with benign gynaecological diseases SCC was also elevated. 59% of the 102 patients with primary and 70% of the 63 patients with recurrent cervical cancer showed pathologic values, CEA was elevated in 32% and 51% respectively; the mean serum concentrations increased with the stage of the disease. 68% of 142 patients with squamous cell carcinoma had elevated levels, in 5 of 9 adenosquamous carcinomas and in 3 of 14 adenocarcinomas SCC was in the pathological range. 13 of 60 patients with breast, endometrial and ovarian cancer showed elevated values. SCC shows a high specificity and a high sensitivity for squamous cell carcinomas of the cervix uteri. The tumor marker might be helpful in the control of the primary therapy and follow-up of cervical cancer patients.
鳞状细胞癌（SCC）抗原于1977年由加藤等人首次在子宫颈癌患者中发现。SCC血清水平可通过放射免疫测定法（雅培）进行检测，在我们的研究中，2.0 ng/ml被视为标准范围的上限。35名健康女性的SCC血清水平均未升高。50例良性妇科疾病患者中只有2例的SCC水平也升高。102例原发性宫颈癌患者中有59%以及63例复发性宫颈癌患者中有70%的SCC值呈病理性升高；癌胚抗原（CEA）升高的比例分别为32%和51%；血清平均浓度随疾病分期增加。142例鳞状细胞癌患者中有68%的SCC水平升高，9例腺鳞癌中有5例以及14例腺癌中有3例的SCC处于病理性范围。60例乳腺癌、子宫内膜癌和卵巢癌患者中有13例的SCC值升高。SCC对子宫颈鳞状细胞癌具有高特异性和高敏感性。该肿瘤标志物可能有助于宫颈癌患者的初始治疗监测及随访。
