Nafziger A N, Bertino J S
Research Institute, Mary Imogene Bassett Hospital, Cooperstown, NY.
Eur J Clin Pharmacol. 1989;37(1):97-100. doi: 10.1007/BF00609434.
Theophylline pharmacokinetic parameters were compared in healthy males and healthy premenopausal females who were matched for age and smoking status. Twenty-four subjects (including five smokers and seven non-smokers of each sex) received a single dose of aminophylline 6 mg.kg-1, orally or by intravenous infusion. Theophylline half-life was significantly shorter in female non-smokers (FNS) versus male non-smokers (MNS), (FNS = 6.0 h; MNS = 9.3 h), and in female smokers (FS) versus male smokers (MS), (FS = 4.6 h; MS = 6.3 h). Total body clearance was significantly different in FNS versus MNS, (FNS = 43.8 ml.min-1.-1(1.73) m-2; MNS = 37.4 ml.min-1.1.73 m-2), but did not reach statistical significance in FS vs. MS, (FS = 64.2 ml.min-1.1(-1).1.73 m-2; MS = 53.1 ml.min-1.1.73 m-2). Volume of distribution did not differ significantly between groups. Sex differences in theophylline pharmacokinetics exist and may reflect differences in drug metabolism.
对年龄和吸烟状况相匹配的健康男性和绝经前健康女性的茶碱药代动力学参数进行了比较。24名受试者（包括每种性别各5名吸烟者和7名非吸烟者）口服或静脉输注单剂量6mg/kg的氨茶碱。女性非吸烟者（FNS）的茶碱半衰期显著短于男性非吸烟者（MNS），（FNS = 6.0小时；MNS = 9.3小时），女性吸烟者（FS）的茶碱半衰期显著短于男性吸烟者（MS），（FS = 4.6小时；MS = 6.3小时）。女性非吸烟者与男性非吸烟者的总体清除率有显著差异，（FNS = 43.8ml·min⁻¹·(1.73)m⁻²；MNS = 37.4ml·min⁻¹·1.73m⁻²），但女性吸烟者与男性吸烟者之间未达到统计学显著差异，（FS = 64.2ml·min⁻¹·1⁻¹·1.73m⁻²；MS = 53.1ml·min⁻¹·1.73m⁻²）。各性别组间分布容积无显著差异。茶碱药代动力学存在性别差异，这可能反映了药物代谢的差异。
