一氧化氮在干细胞多能性维持及缺氧反应调节中的作用。
Role of nitric oxide in the maintenance of pluripotency and regulation of the hypoxia response in stem cells.
作者信息
Beltran-Povea Amparo, Caballano-Infantes Estefania, Salguero-Aranda Carmen, Martín Franz, Soria Bernat, Bedoya Francisco J, Tejedo Juan R, Cahuana Gladys M
机构信息
Amparo Beltran-Povea, Estefania Caballano-Infantes, Franz Martín, Francisco J Bedoya, Juan R Tejedo, Gladys M Cahuana, Andalusian Center for Molecular Biology and Regenerative Medicine-University Pablo de Olavide, CIBERDEM, RED-TERCEL, 41092 Seville, Spain.
出版信息
World J Stem Cells. 2015 Apr 26;7(3):605-17. doi: 10.4252/wjsc.v7.i3.605.
Abstract
Stem cell pluripotency and differentiation are global processes regulated by several pathways that have been studied intensively over recent years. Nitric oxide (NO) is an important molecule that affects gene expression at the level of transcription and translation and regulates cell survival and proliferation in diverse cell types. In embryonic stem cells NO has a dual role, controlling differentiation and survival, but the molecular mechanisms by which it modulates these functions are not completely defined. NO is a physiological regulator of cell respiration through the inhibition of cytochrome c oxidase. Many researchers have been examining the role that NO plays in other aspects of metabolism such as the cellular bioenergetics state, the hypoxia response and the relationship of these areas to stem cell stemness.
摘要
干细胞的多能性和分化是由多个途径调控的整体过程，近年来对这些途径进行了深入研究。一氧化氮（NO）是一种重要分子，它在转录和翻译水平上影响基因表达，并调节多种细胞类型中的细胞存活和增殖。在胚胎干细胞中，NO具有双重作用，控制分化和存活，但其调节这些功能的分子机制尚未完全明确。NO通过抑制细胞色素c氧化酶，是细胞呼吸的生理调节因子。许多研究人员一直在研究NO在代谢的其他方面所起的作用，如细胞生物能量状态、缺氧反应以及这些领域与干细胞干性的关系。
相似文献
1
Role of nitric oxide in the maintenance of pluripotency and regulation of the hypoxia response in stem cells.一氧化氮在干细胞多能性维持及缺氧反应调节中的作用。
World J Stem Cells. 2015 Apr 26;7(3):605-17. doi: 10.4252/wjsc.v7.i3.605.
2
The Role of Nitric Oxide in Stem Cell Biology.一氧化氮在干细胞生物学中的作用。
Antioxidants (Basel). 2022 Mar 3;11(3):497. doi: 10.3390/antiox11030497.
3
Regulation of mitochondrial function and endoplasmic reticulum stress by nitric oxide in pluripotent stem cells.一氧化氮对多能干细胞中线粒体功能和内质网应激的调节
World J Stem Cells. 2017 Feb 26;9(2):26-36. doi: 10.4252/wjsc.v9.i2.26.
4
Nitric Oxide Prevents Mouse Embryonic Stem Cell Differentiation Through Regulation of Gene Expression, Cell Signaling, and Control of Cell Proliferation.一氧化氮通过调节基因表达、细胞信号传导和控制细胞增殖来防止小鼠胚胎干细胞分化。
J Cell Biochem. 2016 Sep;117(9):2078-88. doi: 10.1002/jcb.25513. Epub 2016 Mar 8.
5
Cell metabolism under microenvironmental low oxygen tension levels in stemness, proliferation and pluripotency.微环境低氧张力水平下细胞在干性、增殖和多能性方面的代谢
Curr Mol Med. 2015;15(4):343-59. doi: 10.2174/1566524015666150505160406.
6
Nitric Oxide And Hypoxia Response In Pluripotent Stem Cells.多能干细胞中的一氧化氮和缺氧反应。
Redox Biol. 2015 Aug;5:417-418. doi: 10.1016/j.redox.2015.09.024. Epub 2015 Dec 30.
7
FGF Signaling Pathway: A Key Regulator of Stem Cell Pluripotency.成纤维细胞生长因子信号通路：干细胞多能性的关键调节因子。
Front Cell Dev Biol. 2020 Feb 18;8:79. doi: 10.3389/fcell.2020.00079. eCollection 2020.
8
The stabilization of hypoxia inducible factor modulates differentiation status and inhibits the proliferation of mouse embryonic stem cells.缺氧诱导因子的稳定调节小鼠胚胎干细胞的分化状态并抑制其增殖。
Chem Biol Interact. 2016 Jan 25;244:204-14. doi: 10.1016/j.cbi.2015.12.007. Epub 2015 Dec 23.
9
In or out stemness: comparing growth factor signalling in mouse embryonic stem cells and primordial germ cells.干性的内与外：比较小鼠胚胎干细胞和原始生殖细胞中的生长因子信号传导
Curr Stem Cell Res Ther. 2009 May;4(2):87-97. doi: 10.2174/157488809788167391.
10
The expression of pluripotency and neuronal differentiation markers under the influence of electromagnetic field and nitric oxide.在电磁场和一氧化氮的影响下，多能性和神经元分化标志物的表达。
Mol Cell Neurosci. 2017 Dec;85:19-28. doi: 10.1016/j.mcn.2017.08.005. Epub 2017 Aug 24.
引用本文的文献
1
Multifaceted role of nitric oxide in vascular dementia.一氧化氮在血管性痴呆中的多方面作用。
Med Gas Res. 2025 Dec 1;15(4):496-506. doi: 10.4103/mgr.MEDGASRES-D-24-00158. Epub 2025 Apr 29.
2
Regulation and Pharmacology of the Cyclic GMP and Nitric Oxide Pathway in Embryonic and Adult Stem Cells.胚胎和成体干细胞中环鸟苷酸和一氧化氮途径的调节与药理学
Cells. 2024 Dec 5;13(23):2008. doi: 10.3390/cells13232008.
3
Nitric oxide: an old drug but with new horizons in ophthalmology-a narrative review.一氧化氮：一种古老的药物，但在眼科领域有新的前景——一篇叙述性综述
Ann Transl Med. 2023 Aug 30;11(10):352. doi: 10.21037/atm-22-5634. Epub 2023 Jun 6.
4
Succinate as a New Actor in Pluripotency and Early Development?琥珀酸是多能性和早期发育中的新角色？
Metabolites. 2022 Jul 15;12(7):651. doi: 10.3390/metabo12070651.
5
Long-term hematopoietic stem cells as a parasite niche during treatment failure in visceral leishmaniasis.长期造血干细胞作为内脏利什曼病治疗失败时的寄生虫栖息地。
Commun Biol. 2022 Jun 25;5(1):626. doi: 10.1038/s42003-022-03591-7.
6
The FOXO signaling axis displays conjoined functions in redox homeostasis and stemness.FOXO 信号通路在氧化还原平衡和干细胞特性中具有共同的功能。
Free Radic Biol Med. 2021 Jun;169:224-237. doi: 10.1016/j.freeradbiomed.2021.04.022. Epub 2021 Apr 18.
7
Viability and intracellular nitric oxide generation in the umbilical cord blood CD34CD133 and CD34CD133 cell populations exposed to local anaesthetics.暴露于局部麻醉剂的脐带血CD34⁺CD133⁺和CD34⁺CD133⁻细胞群体的活力及细胞内一氧化氮生成
Cent Eur J Immunol. 2020;45(4):369-376. doi: 10.5114/ceji.2020.103410. Epub 2021 Jan 30.
8
Nitric Oxide in the Control of the Proliferation and Differentiation of Human Hematopoietic Stem and Progenitor Cells.一氧化氮对人类造血干细胞和祖细胞增殖与分化的调控
Front Cell Dev Biol. 2021 Feb 9;8:610369. doi: 10.3389/fcell.2020.610369. eCollection 2020.
9
Contributions of Nitric Oxide to AHR-Ligand-Mediated Keratinocyte Differentiation.一氧化氮对 AHR 配体介导的角质形成细胞分化的贡献。
Int J Mol Sci. 2020 Aug 8;21(16):5680. doi: 10.3390/ijms21165680.
10
Characterization of a de novo sSMC 17 detected in a girl with developmental delay and dysmorphic features.在一名患有发育迟缓及畸形特征的女童中检测到的一条新发17号小环状染色体的特征分析。
Mol Cytogenet. 2017 Mar 23;10:10. doi: 10.1186/s13039-017-0312-x. eCollection 2017.
本文引用的文献
1
Nitric oxide-induced neuronal to glial lineage fate-change depends on NRSF/REST function in neural progenitor cells.一氧化氮诱导的神经元到神经胶质谱系命运转变取决于神经前体细胞中 NRSF/REST 的功能。
Stem Cells. 2014 Sep;32(9):2539-49. doi: 10.1002/stem.1749.
2
AMP-activated protein kinase is involved in induction of protective autophagy in astrocytes exposed to oxygen-glucose deprivation.AMP 活化蛋白激酶参与暴露于氧糖剥夺的星形胶质细胞中保护性自噬的诱导。
Cell Biol Int. 2014 Oct;38(10):1086-97. doi: 10.1002/cbin.10299. Epub 2014 Jun 18.
3
Hypoxia induces re-entry of committed cells into pluripotency.缺氧诱导定向细胞重新进入多能性。
Stem Cells. 2013 Sep;31(9):1737-48. doi: 10.1002/stem.1446.
4
Effects of nitric oxide on cell proliferation: novel insights.一氧化氮对细胞增殖的影响：新的见解。
J Am Coll Cardiol. 2013 Jul 9;62(2):89-95. doi: 10.1016/j.jacc.2013.03.070. Epub 2013 May 9.
5
Metabolic regulation in pluripotent stem cells during reprogramming and self-renewal.多能干细胞在重编程和自我更新过程中的代谢调控。
Cell Stem Cell. 2012 Nov 2;11(5):589-95. doi: 10.1016/j.stem.2012.10.005.
6
Curcumin induces differentiation of embryonic stem cells through possible modulation of nitric oxide-cyclic GMP pathway.姜黄素通过可能调节一氧化氮-cGMP 通路诱导胚胎干细胞分化。
Protein Cell. 2012 Jul;3(7):535-44. doi: 10.1007/s13238-012-2053-2. Epub 2012 Jul 10.
7
HIF-2α suppresses p53 to enhance the stemness and regenerative potential of human embryonic stem cells.缺氧诱导因子 2α（HIF-2α）抑制 p53 以增强人类胚胎干细胞的干性和再生潜能。
Stem Cells. 2012 Aug;30(8):1685-95. doi: 10.1002/stem.1142.
8
Links between metabolism and cancer.代谢与癌症之间的联系。
Genes Dev. 2012 May 1;26(9):877-90. doi: 10.1101/gad.189365.112.
9
Roles of the hypoxia response system in hematopoietic and leukemic stem cells.缺氧反应系统在造血和白血病干细胞中的作用。
Int J Hematol. 2012 May;95(5):478-83. doi: 10.1007/s12185-012-1071-4. Epub 2012 Apr 27.
10
HIF1α induced switch from bivalent to exclusively glycolytic metabolism during ESC-to-EpiSC/hESC transition.HIF1α 诱导 ESC 向 EpiSC/hESC 过渡过程中从二价状态到完全糖酵解代谢的转变。
EMBO J. 2012 May 2;31(9):2103-16. doi: 10.1038/emboj.2012.71. Epub 2012 Mar 23.
Zotero 插件