FOXO 信号通路在氧化还原平衡和干细胞特性中具有共同的功能。
The FOXO signaling axis displays conjoined functions in redox homeostasis and stemness.
机构信息
Department of Molecular, Cell and Systems Biology, College of Natural and Agricultural Sciences, University of California Riverside, Riverside, 92521, CA, USA.
Department of Molecular, Cell and Systems Biology, College of Natural and Agricultural Sciences, University of California Riverside, Riverside, 92521, CA, USA; Stem Cell Center, College of Natural and Agricultural Sciences, University of California Riverside, Riverside, 92521, CA, USA.
出版信息
Free Radic Biol Med. 2021 Jun;169:224-237. doi: 10.1016/j.freeradbiomed.2021.04.022. Epub 2021 Apr 18.
Previous views of reactive oxygen species (ROS) depicted them as harmful byproducts of metabolism as uncontrolled levels of ROS can lead to DNA damage and cell death. However, recent studies have shed light into the key role of ROS in the self-renewal or differentiation of the stem cell. The interplay between ROS levels, metabolism, and the downstream redox signaling pathways influence stem cell fate. In this review we will define ROS, explain how they are generated, and how ROS signaling can influence transcription factors, first and foremost forkhead box-O transcription factors, that shape not only the cellular redox state, but also stem cell fate. Now that studies have illustrated the importance of redox homeostasis and the role of redox signaling, understanding the mechanisms behind this interplay will further shed light into stem cell biology.
先前对活性氧（ROS）的观点将其描绘为代谢的有害副产物，因为 ROS 水平失控会导致 DNA 损伤和细胞死亡。然而，最近的研究揭示了 ROS 在干细胞的自我更新或分化中的关键作用。ROS 水平、代谢和下游氧化还原信号通路之间的相互作用影响干细胞命运。在这篇综述中，我们将定义 ROS，解释它们是如何产生的，以及 ROS 信号如何影响转录因子，首先是叉头框 O 转录因子，这些转录因子不仅塑造细胞的氧化还原状态，还塑造干细胞命运。既然研究已经说明了氧化还原平衡和氧化还原信号作用的重要性，那么理解这种相互作用背后的机制将进一步阐明干细胞生物学。
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