Shahramian I, Noori N M, Teimouri A, Akhlaghi E, Sharafi E
Department of Pediatric, Zabol University of Medical Sciences, Zabol, Iran.
Department of Pediatric, Children and Adolescents Health Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
Iran J Ped Hematol Oncol. 2015;5(1):11-7. Epub 2015 Mar 15.
Polypeptide hormone Leptin suppresses inflammation in the heart muscle and protects heart from diseases. The purpose of this study is to evaluate the relationship between leptin and troponin serum levels with cardiac involvement in patients with major beta thalassemia.
In this cross-sectional study, 70 children with major thalassemia were selected. Two ml blood was taken as sample from all children and after separating serum; the samples were maintained in -20°C temperature. Then, regarding cold chain conditions, the sample were sent to the Biochemistry Lab. Afterwards, leptin and troponin serum levels with the relevant kits and BMI were measured in all children, and information about age and gender was recorded. Collected data were analyzed with SPSS.
The mean of leptin in girls and boys were 2.47 ± 3.13 and 0.96 ± 1.08 respectively which showed a significant difference (t=2.74, p =0.009). A significant correlation was also observed between BMI and leptin (r = 0.374, P = 0.002). Another significant association was found between leptin and age (r = 0.248, P = 0.041). However, a significant inverse correlation between serum ferritin and age (r = - 0.607, P = 0.0001) was discovered. No correlation was found between leptin, troponin, and ferritin.
Since Leptin increases with the advent of cardiac involvement and independent from troponin T, it can be a predictive marker of cardiac involvement in patients with major beta thalassemia.
多肽激素瘦素可抑制心肌炎症并保护心脏免受疾病侵害。本研究旨在评估重型β地中海贫血患者中瘦素和肌钙蛋白血清水平与心脏受累之间的关系。
在这项横断面研究中，选取了70名重型地中海贫血患儿。从所有患儿采集2ml血液作为样本，分离血清后，样本保存在-20°C。然后，按照冷链条件，将样本送至生物化学实验室。之后，使用相关试剂盒测量所有患儿的瘦素和肌钙蛋白血清水平以及体重指数（BMI），并记录年龄和性别信息。收集的数据用SPSS进行分析。
女孩和男孩的瘦素平均值分别为2.47±3.13和0.96±1.08，差异有统计学意义（t=2.74，p =0.009）。BMI与瘦素之间也存在显著相关性（r = 0.374，P = 0.002）。瘦素与年龄之间也发现了另一个显著关联（r = 0.248，P = 0.041）。然而，发现血清铁蛋白与年龄之间存在显著负相关（r = - 0.607，P = 0.0001）。瘦素、肌钙蛋白和铁蛋白之间未发现相关性。
由于瘦素随着心脏受累的出现而增加且独立于肌钙蛋白T，它可以作为重型β地中海贫血患者心脏受累的预测标志物。
