Shahramian I, Akhlaghi E, Ramezani A, Rezaee A, Noori N, Sharafi E
Assistant Professor of Pediatric, Department of Pediatrics, Zabol University of Medical Sciences, Zabol , Iran.
Medical Student, Zabol University of Medical Sciences, Zabol , Iran.
Iran J Ped Hematol Oncol. 2013;3(2):59-63. Epub 2013 Apr 22.
The aim of this study was to evaluate leptin serum levels in patients with major beta thalassemia which was also associated with their ferritin serum levels.
This case-control study was performed on 90 children -6 months to 16 years old, in Zabol, Amir- al- Momenin Hospital. Patients were divided in two groups and were matched in age and sex. All Children were examined and those eligible children who had not known heart disease, iron deficiency anemia, kidney disease, diabetes, fever and systemic diseases were enrolled after taking the informed consent of their parents. After collecting the samples, leptin and ferritin levels of the serum were measured in two groups by ELISA method. Then, the data was analyzed by the related statistical tests and SPSS 20 software.
The mean of the serum levels of leptin and ferritin showed a significant difference in the case and control groups (P-value<0.05). An inverse statistical correlation was found for the serum levels of leptin and ferritin among the studied groups (P-value<0.05). Levels of leptin in the case group showed a significant gender difference (P-value<0.05), while based on BMI and age, no significant difference was observed for the serum levels of leptin in the case group.
Based on the results of this study, major thalassemia reduces serum levels of leptin regardless of age and body mass. The study also found an inverse statistical correlation between serum levels of leptin and ferritin among the studied people.
本研究旨在评估重型β地中海贫血患者的血清瘦素水平及其与血清铁蛋白水平的关系。
本病例对照研究在扎博勒的阿米尔-穆民医院对90名6个月至16岁的儿童进行。患者分为两组，在年龄和性别上进行匹配。对所有儿童进行检查，在获得其父母的知情同意后，纳入那些没有已知心脏病、缺铁性贫血、肾病、糖尿病、发热和全身性疾病的符合条件的儿童。采集样本后，采用ELISA法测定两组血清中的瘦素和铁蛋白水平。然后，通过相关统计检验和SPSS 20软件对数据进行分析。
病例组和对照组血清瘦素和铁蛋白水平的平均值存在显著差异（P值<0.05）。在研究组中，血清瘦素和铁蛋白水平呈负相关（P值<0.05）。病例组中瘦素水平存在显著的性别差异（P值<0.05），而基于BMI和年龄，病例组血清瘦素水平未观察到显著差异。
基于本研究结果，重型地中海贫血无论年龄和体重如何都会降低血清瘦素水平。该研究还发现研究对象血清瘦素和铁蛋白水平之间存在负相关。
