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产志贺毒素大肠杆菌O111：一名患有溶血尿毒综合征并伴有急性脑病的年轻女孩，在血浆置换的同时，通过进行一系列血液透析滤过、类固醇冲击治疗以及使用可溶性血栓调节蛋白，成功得到了救治。

STEC:O111-HUS complicated by acute encephalopathy in a young girl was successfully treated with a set of hemodiafiltration, steroid pulse, and soluble thrombomodulin under plasma exchange.

作者信息

Yada Noritaka, Fujioka Masayuki, Bennett Charles L, Inoki Kazuya, Miki Toyokazu, Watanabe Akihiko, Yoshida Toshiko, Hayakawa Masaki, Matsumoto Masanori, Fujimura Yoshihiro

机构信息

Department of Emergency and Critical Care Medicine, Yodogawa Christian Hospital Osaka, Japan.

Department of Emergency and Critical Care Medicine, Nara Medical University Kashihara, Japan.

出版信息

Clin Case Rep. 2015 Apr;3(4):208-12. doi: 10.1002/ccr3.196. Epub 2015 Feb 2.

DOI:10.1002/ccr3.196
PMID:25914810
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4405303/
Abstract

We report a 14-year-old girl, who developed shigatoxin-producing E. coli (STEC)-HUS complicated by encephalopathy. She was successfully treated with hemodiafiltration, high-dose methylprednisolone pulse therapy, and soluble recombinant thrombomodulin under plasma exchange. von Willebrand factor multimers analysis provides potential insights into how the administered therapies might facilitate successful treatment of STEC-HUS.

摘要

我们报告了一名14岁女孩，她患上了产志贺毒素大肠杆菌（STEC）-溶血尿毒综合征，并伴有脑病。她在血浆置换的情况下，通过血液透析滤过、大剂量甲泼尼龙冲击疗法和可溶性重组血栓调节蛋白成功得到治疗。血管性血友病因子多聚体分析为所给予的治疗方法如何促进STEC-溶血尿毒综合征的成功治疗提供了潜在的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b660/4405303/b867f9e8a5e5/ccr30003-0208-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b660/4405303/d25bbd15894f/ccr30003-0208-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b660/4405303/b867f9e8a5e5/ccr30003-0208-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b660/4405303/d25bbd15894f/ccr30003-0208-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b660/4405303/b867f9e8a5e5/ccr30003-0208-f2.jpg

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2
Cerebral magnetic resonance imaging findings in adults with haemolytic uraemic syndrome following an infection with Escherichia coli, subtype O104:H4.感染产志贺毒素大肠杆菌O104:H4亚型后发生溶血尿毒综合征的成人患者的脑磁共振成像结果
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Cytokine profiles of patients with enterohemorrhagic Escherichia coli O111-induced hemolytic-uremic syndrome.
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Curr Neuropharmacol. 2021;19(1):24-44. doi: 10.2174/1570159X18666200220143001.
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Virulence Genes, Shiga Toxin Subtypes, Serogroups, and Clonal Relationship of Shiga Toxin-Producing Strains Isolated from Livestock and Companion Animals.从家畜和伴侣动物中分离出的产志贺毒素菌株的毒力基因、志贺毒素亚型、血清群及克隆关系
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