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原发性急性爱泼斯坦-巴尔病毒感染后，成功治疗一名儿童的活动性系统性爱泼斯坦-巴尔病毒阳性T细胞淋巴增殖性疾病，采用来自HLA不匹配同胞供体的即刻异基因清髓性造血干细胞移植。

Successful treatment of immediate allogeneic myeloablative hematopoietic stem cell transplantation from a HLA-mismatched sibling donor for active systemic epstein-barr virus-positive T-cell lymphoproliferative disease of childhood following primary acute epstein-barr virus infection.

作者信息

Kakinoki Yasutaka, Matsuoka Satomi, Hashiguchi Junichi, Chiba Koji, Miyake Takayoshi

机构信息

Department of Hematology, Asahikawa City Hospital Asahikawa, Japan.

Department of Hematology, Hokkaido University Graduate School of Medicine Sapporo, Japan.

出版信息

Clin Case Rep. 2015 Apr;3(4):231-6. doi: 10.1002/ccr3.204. Epub 2015 Feb 2.

DOI:10.1002/ccr3.204
PMID:25914814
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4405307/
Abstract

A 22-year-old female was admitted for sustained high fever and diagnosed with systemic Epstein-Barr virus-positive T-cell lymphoproliferative disease. As her clinical course was so aggressive, she immediately underwent allogeneic myeloablative bone marrow transplantation from an HLA-mismatched sibling donor on hospital day 46. The patient has remained in complete remission for 3 years.

摘要

一名22岁女性因持续高热入院，被诊断为系统性爱泼斯坦-巴尔病毒阳性T细胞淋巴增殖性疾病。由于其临床病程进展迅速，她在住院第46天立即接受了来自一名HLA配型不合的同胞供者的异基因清髓性骨髓移植。该患者已完全缓解3年。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea5a/4405307/dbf4f552476e/ccr30003-0231-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea5a/4405307/ef030176f0af/ccr30003-0231-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea5a/4405307/dbf4f552476e/ccr30003-0231-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea5a/4405307/ef030176f0af/ccr30003-0231-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea5a/4405307/dbf4f552476e/ccr30003-0231-f2.jpg

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Blood. 2012 Jan 19;119(3):673-86. doi: 10.1182/blood-2011-10-381921. Epub 2011 Nov 16.
2
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J Clin Exp Hematop. 2011;51(1):57-61. doi: 10.3960/jslrt.51.57.
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Excellent outcome of allogeneic hematopoietic SCT with reduced-intensity conditioning for the treatment of chronic active EBV infection.
异基因造血干细胞移植联合低强度预处理治疗慢性活动性 EBV 感染的良好结果。
Bone Marrow Transplant. 2011 Jan;46(1):77-83. doi: 10.1038/bmt.2010.122. Epub 2010 May 24.
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Viral infections associated with haemophagocytic syndrome.与噬血细胞综合征相关的病毒感染。
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