室温下胺类与甲醇的N-甲基化反应。
N-methylation of amines with methanol at room temperature.
作者信息
Tsarev Vasily N, Morioka Yuna, Caner Joaquim, Wang Qing, Ushimaru Richiro, Kudo Akihiko, Naka Hiroshi, Saito Susumu
机构信息
†Research Center for Materials Science and Graduate School of Science, Nagoya University, Chikusa, Nagoya 464-8602, Japan.
‡Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, 1-3 Kagurazaka, Shinjyuku, Tokyo 162-8601, Japan.
出版信息
Org Lett. 2015 May 15;17(10):2530-3. doi: 10.1021/acs.orglett.5b01063. Epub 2015 Apr 27.
N-Methylation of amines with methanol proceeds at room temperature in the presence of a silver-loaded titanium dioxide (Ag/TiO2) photocatalyst under UV-vis light irradiation. This method allows facile synthesis/isolation of N-methylamines bearing various functional groups including N-benzyl, N-allyl, N-Boc, hydroxyl, ether, acetal, carboxamide, formamide, and olefin groups.
在紫外-可见光照射下，在负载银的二氧化钛（Ag/TiO₂）光催化剂存在的条件下，胺与甲醇的N-甲基化反应在室温下进行。该方法能够简便地合成/分离带有各种官能团的N-甲基胺，这些官能团包括N-苄基、N-烯丙基、N-Boc、羟基、醚、缩醛、羧酰胺、甲酰胺和烯烃基团。
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