Nacu Aliona, Andersen Jintana Bunpan, Lisnic Vitalie, Owe Jone Furlund, Gilhus Nils Erik
a Department of Neurology , Haukeland University Hospital , Bergen , Norway .
Autoimmunity. 2015;48(6):362-8. doi: 10.3109/08916934.2015.1030614. Epub 2015 Apr 27.
Myasthenia gravis (MG) is a rare autoimmune disease of skeletal muscle endplates. MG subgroup is relevant for comorbidity, but usually not accounted for. MG patients have an increased risk for complicating autoimmune diseases, most commonly autoimmune thyroid disease, systemic lupus erythematosus and rheumatoid arthritis. In this review, we present concomitant autoimmune disorders associated with the different MG subgroups, and show how this influences treatment and prognosis. Concomitant MG should always be considered in patients with an autoimmune disorder and developing new neuromuscular weakness, fatigue or respiratory failure. When a second autoimmune disorder is suspected, MG should be included as a differential diagnosis.
重症肌无力（MG）是一种罕见的骨骼肌终板自身免疫性疾病。MG亚组与合并症相关，但通常未被考虑在内。MG患者并发自身免疫性疾病的风险增加，最常见的是自身免疫性甲状腺疾病、系统性红斑狼疮和类风湿性关节炎。在本综述中，我们介绍了与不同MG亚组相关的伴随自身免疫性疾病，并展示了这如何影响治疗和预后。自身免疫性疾病患者出现新的神经肌肉无力、疲劳或呼吸衰竭时，应始终考虑合并MG的情况。当怀疑存在第二种自身免疫性疾病时，应将MG纳入鉴别诊断。
