Shao Tianrui, Lu Jing, Kang Hailan, Zhang Yibin, Lan Tianye, Wang Jian
Changchun University of Chinese Medicine, Jilin, China.
Research Center of Traditional Chinese Medicine, The Affiliated Hospital of Changchun University of Chinese Medicine, Jilin, China.
Endocrine. 2025 Apr;88(1):24-35. doi: 10.1007/s12020-024-04143-1. Epub 2024 Dec 27.
With the prolongation of life expectancy in patients with myasthenia gravis, the number of comorbidities is increasing. Diabetes mellitus is one of the main comorbidities faced by patients with myasthenia gravis. However, there is not enough epidemiological information on diabetes mellitus. Given these limitations, the purpose of this study was to review the prevalence of diabetes mellitus in patients with myasthenia gravis and whether the myasthenia gravis is associated with an increased risk of gestational diabetes mellitus.
PubMed, Embase, and Web of Science were searched for articles published prior to February 2024. Endnote 21 software was used to manage all relevant records. Review Manager version 5.4 and Stata version 18.0 software were used for the statistical analysis. Funnel plots and Egger's test were used to assess publication bias.
Twenty-four articles met the inclusion criteria and were included in the study. Among 23,516 myasthenia gravis patients, the prevalence of diabetes mellitus was 17% (95% CI 1222%). In addition, the meta-analysis of the two studies showed that myasthenia gravis was significantly associated with an increased risk of gestational diabetes mellitus (OR = 1.56, 95% CI 1.261.93, p < 0.01).
Among the comorbidities of myasthenia gravis patients, diabetes mellitus is common, and the risk of gestational diabetes mellitus is increased in myasthenia gravis patients. These findings remind us that diabetes mellitus seems to be an important issue in the clinical management of myasthenia gravis patients and requires more attention.
随着重症肌无力患者预期寿命的延长，其合并症数量不断增加。糖尿病是重症肌无力患者面临的主要合并症之一。然而，关于糖尿病的流行病学信息并不充分。鉴于这些局限性，本研究旨在回顾重症肌无力患者中糖尿病的患病率，以及重症肌无力是否与妊娠期糖尿病风险增加相关。
检索了PubMed、Embase和Web of Science数据库中截至2024年2月发表的文章。使用Endnote 21软件管理所有相关记录。采用Review Manager 5.4版和Stata 18.0版软件进行统计分析。使用漏斗图和Egger检验评估发表偏倚。
24篇文章符合纳入标准并被纳入研究。在23516例重症肌无力患者中，糖尿病患病率为17%（95%CI 1222%）。此外，两项研究的荟萃分析表明，重症肌无力与妊娠期糖尿病风险增加显著相关（OR = 1.56，95%CI 1.261.93，p < 0.01）。
在重症肌无力患者的合并症中，糖尿病较为常见，且重症肌无力患者患妊娠期糖尿病的风险增加。这些发现提醒我们，糖尿病似乎是重症肌无力患者临床管理中的一个重要问题，需要更多关注。
