Mozzati Marco, Mortellaro Carmen, Gallesio Giorgia, Ruggiero Tiziana, Pol Renato
*SIOM Oral Surgery and Implantology Center, Turin, Italy †Department of Health Sciences "A. Avogadro," University of Eastern Piedmont, Novara, Italy ‡Trainer, Oral Surgery Unit, Dentistry Section §Consultant, Oral Surgery Unit, Dentistry Section, Department of Biomedical Sciences and Human Oncology, University of Turin, Turin, Italy.
J Craniofac Surg. 2015 May;26(3):772-5. doi: 10.1097/SCS.0000000000001507.
Denture-induced fibrous hyperplasia is a fibrous connective tissue lesion that commonly occurs in oral mucosa in patients showing important alveolar ridge atrophy. In this study, we propose Plasma Rich in Growth Factors (PRGF) to overcome constrains of traditional surgical treatment. Herein, we demonstrated that PRGF represents an autologous source of growth factors able to reduce the healing time of the alveolar mucosa and the discomfort of those patients. These properties are the result of PRGF's precise biological features that result in the following: reduction of duration and intensity of postsurgical pain, acceleration of re-epithelialization of the wound, and reduction of bleeding events and of edema. In conclusion, we showed that using PRGF on patients affected by denture-induced fibrous hyperplasia allows a short healing time, thereby reducing complications and overall improving their quality of life. The aims of this study were to evaluate the influence of PRGF-ENDORET on secondary re-epithelialization in vestibuloplasty after excision of denture irritation fibrous hyperplasia, with an explorative randomized case control trial with 10 patients, 5 patients treated with PRGF and 5 patients with traditional hemostasis, and to analyze differences with simple surgery, considering postoperative rapidity of re-epithelialization, comfort, and discomfort of patients, pain, swelling, and infections.
义齿性纤维增生是一种纤维结缔组织病变，常见于牙槽嵴严重萎缩患者的口腔黏膜。在本研究中，我们提出使用富含生长因子的血浆（PRGF）来克服传统手术治疗的局限性。在此，我们证明PRGF是一种自体生长因子来源，能够缩短牙槽黏膜的愈合时间并减轻患者的不适。这些特性是PRGF精确生物学特性的结果，具体如下：缩短术后疼痛的持续时间和强度、加速伤口的再上皮化、减少出血事件和水肿。总之，我们表明，对义齿性纤维增生患者使用PRGF可缩短愈合时间，从而减少并发症并全面改善他们的生活质量。本研究的目的是通过一项探索性随机病例对照试验，评估PRGF-ENDORET对义齿性刺激纤维增生切除术后前庭成形术中二次再上皮化的影响，该试验有10名患者，5名患者接受PRGF治疗，5名患者采用传统止血方法，并分析与单纯手术的差异，考虑术后再上皮化的速度、患者的舒适度和不适、疼痛、肿胀及感染情况。
