肾疾病患者全血抗体依赖性细胞介导的细胞毒性评估。
Assessment of whole blood for antibody-dependent cell-mediated cytotoxicity in kidney patients.
作者信息
Dupont E
出版信息
Proc Eur Dial Transplant Assoc. 1977;14:321-7.
A test using whole blood for antibody-dependent cell-mediated cytotoxicity has been assessed in kidney patients. The antibody-coated target system comprised lymphocytes isolated from a normal donor sensitised with rabbit anti-human lymphocyte serum. Comparison of results obtained with whole blood and isolated lymphocytes from the same patients shows that the whole blood test amplifies the differences between normal subjects, dialysis and transplant patients. It probably combines the effects of depressed lymphocyte function and lymphopenia and thus represent a more physiological in vitro correlate for in vivo immune function.
一种用于抗体依赖性细胞介导的细胞毒性的全血检测方法已在肾病患者中进行了评估。抗体包被的靶细胞系统由从用兔抗人淋巴细胞血清致敏的正常供体中分离出的淋巴细胞组成。对同一患者的全血检测结果与分离淋巴细胞检测结果的比较表明，全血检测放大了正常受试者、透析患者和移植患者之间的差异。它可能综合了淋巴细胞功能低下和淋巴细胞减少的影响，因此代表了体内免疫功能更具生理性的体外相关指标。
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