Iida Hiroshi, Inamori Masahiko, Okuno Kotone, Sekino Yusuke, Sakai Eiji, Okubo Hidenori, Higurashi Takuma, Endo Hiroki, Hosono Kunihiro, Yoneda Masato, Koide Tomoko, Takahashi Hirokazu, Goto Ayumu, Kubota Kensuke, Saito Satoru, Maeda Shin, Nakajima Atsushi, Gotoh Eiji
Hepatogastroenterology. 2015 Mar-Apr;62(138):493-6.
BACKGROUND/AIMS: The aim of our study was to investigate the inhibitory effects on gastric acid secretion of a single oral dose of a proton pump inhibitor, esomeprazole 20 mg and omeprazole 20 mg.
A total of 14 Helicobacter pylori-negative male subjects participated in this study. Intragastric pH was monitored continuously for 6 hours after a single oral dose of omeprazole 20 mg and a single oral dose of esomeprazole 20 mg. Each administration was separated by a 7-day washout period.
During the 6-hour study period, the average pH after administration of esomeprazole was higher than that after the administration of omeprazole. Also during the 6-hour study period, each of pH > 2, 3, 3.5, 4, and 5 was maintained for a longer duration after administration of esomeprazole 20 mg than after administration of omeprazole 20 mg (median: 75.4% vs. 53.8%, p = 0.0138; 52.1% vs. 33.4%, p = 0.0188; 45.8% vs. 28.2%, p = 0.0262; 42.5% vs. 20.7%, p = 0.0414; 35.8% vs. 11.6%, p = 0.0262; respectively).
In Helicobacter pylori-negative healthy male subjects, single oral administration of esomeprazole 20 mg increased the intragastric pH more rapidly than single oral administration of omeprazole 20 mg.
背景/目的：我们研究的目的是调查单次口服一剂质子泵抑制剂埃索美拉唑20毫克和奥美拉唑20毫克对胃酸分泌的抑制作用。
共有14名幽门螺杆菌阴性的男性受试者参与了本研究。在单次口服20毫克奥美拉唑和单次口服20毫克埃索美拉唑后，连续6小时监测胃内pH值。每次给药间隔7天的洗脱期。
在6小时的研究期间，服用埃索美拉唑后的平均pH值高于服用奥美拉唑后的平均pH值。同样在6小时的研究期间，服用20毫克埃索美拉唑后，pH>2、3、3.5、4和5的每种情况维持的时间都比服用20毫克奥美拉唑后更长（中位数：75.4%对53.8%，p = 0.0138；52.1%对33.4%，p = 0.0188；45.8%对28.2%，p = 0.0262；42.5%对20.7%，p = 0.0414；35.8%对11.6%，p = 0.0262；分别）。
在幽门螺杆菌阴性的健康男性受试者中，单次口服20毫克埃索美拉唑比单次口服20毫克奥美拉唑能更快地提高胃内pH值。
