AGBL2对胃癌细胞增殖及化疗耐药性的影响。
Effects of AGBL2 on cell proliferation and chemotherapy resistance of gastric cancer.
作者信息
Zhu Haitao, Zheng Zhichao, Zhang Jianjun, Liu Xiaoping, Liu Yang, Yang Wei, Liu Yong, Zhang Tao, Zhao Yan, Liu Yanqing, Su Xiaohui, Gu Xiaohu
出版信息
Hepatogastroenterology. 2015 Mar-Apr;62(138):497-502.
BACKGROUND/AIMS: The present study aimed to investigate the expression status of AGBL2 and its inhibitor latexin, and elucidate their clinical implications in gastric cancer.
METHODOLOGY
AGBL2 expression status was examined in gastric cancer cells and 256 gastric cancer specimens by immunohistochemistry staining. The relationship between AGBL2 protein expression and clinicopathological parameters and prognosis was subsequently determined.
RESULTS
AGBL2 expression was determined to be related to pathological tumor and nodal stages by Spearman's regression correlation analysis. The Cox regression test identified AGBL2 protein expression as an independent prognostic factor. AGBL2 and latexin were- found to be related to proliferation and chemotherapy resistance. The 2 proteins also formed immune com- plexes in immunoprecipitation experiments.
CONCLUSIONS
Our results demonstrate that AGBL2 interacts with latexin, regulating the tubulin tyrosination cycle. It is therefore a potential target for intervention.
背景/目的：本研究旨在调查AGBL2及其抑制剂latexin的表达情况，并阐明它们在胃癌中的临床意义。
方法
通过免疫组织化学染色检测胃癌细胞和256例胃癌标本中AGBL2的表达情况。随后确定AGBL2蛋白表达与临床病理参数及预后之间的关系。
结果
通过Spearman回归相关分析确定AGBL2表达与肿瘤病理分期和淋巴结分期相关。Cox回归检验确定AGBL2蛋白表达为独立的预后因素。发现AGBL2和latexin与增殖和化疗耐药有关。在免疫沉淀实验中，这两种蛋白还形成了免疫复合物。
结论
我们的结果表明，AGBL2与latexin相互作用，调节微管蛋白酪氨酸化循环。因此，它是一个潜在的干预靶点。
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