Li Xiaobao, Liu Yongfeng, Cao Bo, Liu Bin, Bai Tiecheng, Li Xiaoyong, Mei Leyuan, Che Xiangming
Hepatogastroenterology. 2015 Mar-Apr;62(138):507-11.
BACKGROUND/AIMS: This study aimed to investigate the role of metastatic lymph node ratio (MLR) in the evaluation of prognosis of patients with gastric cancer at different T stages.
Clinical information was reviewed retrospectively in a total 535 patients who underwent surgery for gastric cancer. The prognostic value of MLR was compared with that of pN determined according to the UICC/AJCC guidelines (7th Edition), and the characteristics and advantages of MLR were analyzed. Moreover, the role of MLR in the evaluation of prognosis of patients with gastric cancer at different pT stages was investigated.
Univariate Kaplan-Meier method was used for the analysis of survival, and the results showed that MLR was closely associated with the prognosis of these patients. Multivariate analysis with Cox proportional hazards regression model showed that MLR was a major independent risk factor in the prognosis of gastric cancer patients. The area under the ROC curve of MLR in predicting the death of gastric cancer patients within 5 years after surgery was not associated with pN stage. MLR was effective in predicting the prognosis of patients with stage pT2 or pT3 gastric cancer (P < 0.05).
MLR is an independent risk factor in the prognosis of gastric cancer. MLR has a prognostic ability comparable to that of pN stage in gastric cancer. Thus, it is more reliable than pN in the evaluation of prognosis of gastric cancer patients, especially those with stage pT2-pT3 gastric cancer.
背景/目的：本研究旨在探讨转移淋巴结比率（MLR）在评估不同T分期胃癌患者预后中的作用。
回顾性分析535例行胃癌手术患者的临床资料。将MLR的预后价值与根据UICC/AJCC指南（第7版）确定的pN的预后价值进行比较，并分析MLR的特点和优势。此外，研究MLR在评估不同pT分期胃癌患者预后中的作用。
采用单因素Kaplan-Meier法分析生存率，结果显示MLR与这些患者的预后密切相关。Cox比例风险回归模型多因素分析显示，MLR是胃癌患者预后的主要独立危险因素。MLR预测胃癌患者术后5年内死亡的ROC曲线下面积与pN分期无关。MLR对pT2或pT3期胃癌患者的预后有预测作用（P<0.05）。
MLR是胃癌预后的独立危险因素。MLR在胃癌中的预后评估能力与pN分期相当。因此，在评估胃癌患者，尤其是pT2-pT3期胃癌患者的预后时，MLR比pN更可靠。
