Franklyn Joshua, George Sam V, Yacob Myla, Abraham Vijay, Chandran Sudhakar, Sebastian Tunny, Samarasam Inian
Upper GI Surgery Unit, Department of General Surgery Unit 3, Christian Medical College, Vellore, India .
J Gastric Cancer. 2017 Mar;17(1):63-73. doi: 10.5230/jgc.2017.17.e7. Epub 2017 Mar 20.
Data on operable gastric cancer from India is sparse. The purpose of this study was to investigate the clinical details, histopathological demographics, and 5-year overall survival (OS) and disease free survival (DFS) associated with operable, non-metastatic gastric cancer in a dedicated upper gastrointestinal (GI) surgical unit in India.
Data for patients diagnosed with operable gastric cancer between January 2006 and December 2014 were retrospectively analyzed. Data were collected from electronic hospital records in addition to mail and telephonic interviews when possible.
A total of 427 patients were included. The tumor was located in the pyloro-antral region in 263 patients (61.7%). Subtotal gastrectomy was performed in 291 patients and total gastrectomy in 136 patients. Tumor stage classification revealed 43 patients (10.0%) with stage I, 40 patients (9.4%) with stage IIA, 59 patients (13.9%) with stage IIB, 76 patients (17.8%) with stage IIIA, 96 patients (22.5%) with stage IIIB, and 113 patients (26.4%) with stage IIIC disease. Follow-up data were available for 71.6% of the patients with a mean duration of 32.4 months. Five-year DFS and OS were 39% and 59%, respectively.
Despite presenting at an advanced stage, the 5-year DFS and OS of patients with operable gastric cancer treated at a dedicated upper GI unit of a tertiary care center in India was good.
来自印度的可手术治疗胃癌的数据稀少。本研究的目的是调查印度一家专门的上消化道（GI）外科病房中与可手术治疗的非转移性胃癌相关的临床细节、组织病理学人口统计学特征以及5年总生存率（OS）和无病生存率（DFS）。
对2006年1月至2014年12月期间诊断为可手术治疗胃癌的患者数据进行回顾性分析。除了邮件和电话访谈外，还从电子医院记录中收集数据（如有可能）。
共纳入427例患者。263例患者（61.7%）的肿瘤位于幽门窦区。291例行胃次全切除术，136例行全胃切除术。肿瘤分期显示，43例（10.0%）为I期，40例（9.4%）为IIA期，59例（13.9%）为IIB期，76例（17.8%）为IIIA期，96例（22.5%）为IIIB期，113例（26.4%）为IIIC期。71.6%的患者有随访数据，平均随访时间为32.4个月。5年DFS和OS分别为39%和59%。
尽管就诊时处于晚期，但在印度一家三级医疗中心的专门上消化道病房接受治疗的可手术治疗胃癌患者的5年DFS和OS良好。
